L Miguel Martins
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Explore the profile of L Miguel Martins including associated specialties, affiliations and a list of published articles.
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51
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2106
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Recent Articles
1.
Yu Y, Chen C, Celardo I, Tan B, Hurcomb J, Leal N, et al.
Cell Death Dis
. 2024 Nov;
15(11):856.
PMID: 39582067
Alzheimer's disease (AD) is the most common form of age-related dementia. In AD, the death of neurons in the central nervous system is associated with the accumulation of toxic amyloid...
2.
Buckley N, Craxton A, Sun X, Panatta E, Pinon L, Beier S, et al.
Cell Death Dis
. 2024 Nov;
15(11):807.
PMID: 39516459
Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of numerous diseases. We have identified a novel function of the p53 family protein TAp73 in regulating mitochondrial dynamics....
3.
Yu Y, Martins L
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928008
Mitochondrial one-carbon metabolism provides carbon units to several pathways, including nucleic acid synthesis, mitochondrial metabolism, amino acid metabolism, and methylation reactions. Late-onset Alzheimer's disease is the most common age-related neurodegenerative...
4.
Wilson E, Yu Y, Leal N, Woodward J, Patikas N, Morris J, et al.
Cell Death Dis
. 2024 Mar;
15(3):203.
PMID: 38467609
Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of...
5.
OFarrell F, Aleyakpo B, Mustafa R, Jiang X, Pinto R, Elliott P, et al.
Sci Rep
. 2023 Nov;
13(1):20616.
PMID: 37996473
Biological pathways between alcohol consumption and alcohol liver disease (ALD) are not fully understood. We selected genes with known effect on (1) alcohol consumption, (2) liver function, and (3) gene...
6.
Fedele G, Loh S, Celardo I, Leal N, Lehmann S, Costa A, et al.
Nat Aging
. 2023 Apr;
2(4):317-331.
PMID: 37117744
The innate immune response mounts a defense against foreign invaders and declines with age. An inappropriate induction of this response can cause diseases. Previous studies showed that mitochondria can be...
7.
Popovic R, Yu Y, Leal N, Fedele G, Loh S, Martins L
Dis Model Mech
. 2023 Apr;
16(4).
PMID: 37083954
Eukaryotic Tribbles proteins are pseudoenzymes that regulate multiple aspects of intracellular signalling. Both Drosophila melanogaster and mammalian members of this family of pseudokinases act as negative regulators of insulin signalling....
8.
Popovic R, Mukherjee A, Leal N, Morris L, Yu Y, Loh S, et al.
Cell Death Dis
. 2023 Mar;
14(3):206.
PMID: 36949073
Parkinson's disease (PD) is characterised by selective death of dopaminergic (DA) neurons in the midbrain and motor function impairment. Gastrointestinal issues often precede motor deficits in PD, indicating that the...
9.
Travaglio M, Michopoulos F, Yu Y, Popovic R, Foster E, Coen M, et al.
Dis Model Mech
. 2023 Jan;
16(1).
PMID: 36695500
Parkinson's disease (PD), an age-dependent neurodegenerative disease, is characterised by the selective loss of dopaminergic neurons in the substantia nigra (SN). Mitochondrial dysfunction is a hallmark of PD, and mutations...
10.
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies
Graham C, Stefanatos R, Yek A, Spriggs R, Loh S, Uribe A, et al.
Geroscience
. 2022 Mar;
44(4):1961-1974.
PMID: 35355221
Mitochondrial reactive oxygen species (mtROS) are cellular messengers essential for cellular homeostasis. In response to stress, reverse electron transport (RET) through respiratory complex I generates high levels of mtROS. Suppression...