L L Leung
Overview
Explore the profile of L L Leung including associated specialties, affiliations and a list of published articles.
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62
Citations
1123
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Recent Articles
1.
Hall S, Gibbs C, Leung L
Thromb Haemost
. 2002 Jan;
86(6):1466-74.
PMID: 11776315
Thrombin binding to fibrin may be important in localizing thrombin to the site of vascular injury. However, fibrin-bound thrombin retains its catalytic activity toward fibrinogen, and may be prothrombotic under...
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An extensive interaction interface between thrombin and factor V is required for factor V activation
Myles T, Yun T, Hall S, Leung L
J Biol Chem
. 2001 Apr;
276(27):25143-9.
PMID: 11312264
The interaction interface between human thrombin and human factor V (FV), necessary for complex formation and cleavage to generate factor Va, was investigated using a site-directed mutagenesis strategy. Fifty-three recombinant...
4.
Ramakrishnan V, DeGuzman F, Bao M, Hall S, Leung L, Phillips D
Proc Natl Acad Sci U S A
. 2001 Feb;
98(4):1823-8.
PMID: 11172035
Glycoprotein (GP) V is a major substrate cleaved by the protease thrombin during thrombin-induced platelet activation. Previous analysis of platelets from GP V-null mice suggested a role for GP V...
5.
Leung L, Hall S
Trends Cardiovasc Med
. 2001 Jan;
10(2):89-92.
PMID: 11150736
Thrombin is an allosteric enzyme that interacts with multiple procoagulant substrates such as specific clotting factors and cell surface thrombin receptors, as well as the anticoagulant substrate protein C. Functional...
6.
Hall S, Nagashima M, Zhao L, Morser J, Leung L
J Biol Chem
. 1999 Aug;
274(36):25510-6.
PMID: 10464282
A collection of 56 purified thrombin mutants, in which 76 charged or polar surface residues on thrombin were mutated to alanine, was used to identify key residues mediating the interactions...
7.
Murphy J, McGregor J, Leung L
Br J Haematol
. 1998 Sep;
102(4):957-64.
PMID: 9734646
This study investigated the interaction of apoptotic polymorphonuclear neutrophils (PMN) with thrombospondin (TSP), an important event mediating the clearance of apoptotic neutrophils by macrophages. We developed an in vitro assay...
8.
Hall S, Gibbs C, Leung L
Cell Mol Life Sci
. 1997 Nov;
53(9):731-6.
PMID: 9368669
Thrombin is a serine proteinase that can interact with a large number of diverse macromolecular substrates, which results in either a procoagulant or anticoagulant effect. These divergent properties are physiologically...
9.
Leung L, Gibbs C
Thromb Haemost
. 1997 Jul;
78(1):577-80.
PMID: 9198219
The procoagulant and anticoagulant functions of thrombin are controlled physiologically by allosteric changes induced by Na+ and vascular cell-surface TM. Key residues that mediate Na+ interaction with thrombin have been...
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