S W Hall
Overview
Explore the profile of S W Hall including associated specialties, affiliations and a list of published articles.
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63
Citations
737
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Recent Articles
1.
Hall S, Gibbs C, Leung L
Thromb Haemost
. 2002 Jan;
86(6):1466-74.
PMID: 11776315
Thrombin binding to fibrin may be important in localizing thrombin to the site of vascular injury. However, fibrin-bound thrombin retains its catalytic activity toward fibrinogen, and may be prothrombotic under...
2.
De Cristofaro R, De Candia E, Landolfi R, Rutella S, Hall S
Biochemistry
. 2001 Oct;
40(44):13268-73.
PMID: 11683636
The activation of human platelets by alpha-thrombin is mediated in part by cleavage of the protease-activated receptor (PAR) 1 and 4 and by the glycoprotein (Ib)alpha, (Gp(Ib)alpha), which binds with...
3.
An extensive interaction interface between thrombin and factor V is required for factor V activation
Myles T, Yun T, Hall S, Leung L
J Biol Chem
. 2001 Apr;
276(27):25143-9.
PMID: 11312264
The interaction interface between human thrombin and human factor V (FV), necessary for complex formation and cleavage to generate factor Va, was investigated using a site-directed mutagenesis strategy. Fifty-three recombinant...
4.
Ramakrishnan V, DeGuzman F, Bao M, Hall S, Leung L, Phillips D
Proc Natl Acad Sci U S A
. 2001 Feb;
98(4):1823-8.
PMID: 11172035
Glycoprotein (GP) V is a major substrate cleaved by the protease thrombin during thrombin-induced platelet activation. Previous analysis of platelets from GP V-null mice suggested a role for GP V...
5.
Leung L, Hall S
Trends Cardiovasc Med
. 2001 Jan;
10(2):89-92.
PMID: 11150736
Thrombin is an allosteric enzyme that interacts with multiple procoagulant substrates such as specific clotting factors and cell surface thrombin receptors, as well as the anticoagulant substrate protein C. Functional...
6.
De Candia E, Hall S, Rutella S, Landolfi R, Andrews R, De Cristofaro R
J Biol Chem
. 2000 Nov;
276(7):4692-8.
PMID: 11084032
The activation of human platelets by alpha-thrombin is mediated at least in part by cleavage of protease-activated G-protein-coupled receptors, PAR-1 and PAR-4. Platelet glycoprotein Ibalpha also has a high affinity...
7.
Reddy N, Hall S, MacKintosh F
Arch Intern Med
. 1999 Dec;
159(22):2706-10.
PMID: 10597761
Background: Clinical observations suggest an increased incidence of bleeding and thrombosis in association with a shortened partial thromboplastin time (PTT). Objective: To determine whether abnormally fast PTTs are associated with...
8.
Hall S, Nagashima M, Zhao L, Morser J, Leung L
J Biol Chem
. 1999 Aug;
274(36):25510-6.
PMID: 10464282
A collection of 56 purified thrombin mutants, in which 76 charged or polar surface residues on thrombin were mutated to alanine, was used to identify key residues mediating the interactions...
9.
Ritter Jr H, Gralla R, Hall S, Wada J, Friedman C, Hand L, et al.
Cancer Invest
. 1998 Mar;
16(2):87-93.
PMID: 9512674
The safety and efficacy of granisetron (10 micrograms/kg and 40 micrograms/kg) were evaluated during a second (n = 393) and third (n = 200) cycle of chemotherapy in this multicenter,...
10.
Hall S, Gibbs C, Leung L
Cell Mol Life Sci
. 1997 Nov;
53(9):731-6.
PMID: 9368669
Thrombin is a serine proteinase that can interact with a large number of diverse macromolecular substrates, which results in either a procoagulant or anticoagulant effect. These divergent properties are physiologically...