L L Brunton
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Explore the profile of L L Brunton including associated specialties, affiliations and a list of published articles.
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74
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Recent Articles
1.
Zambon A, Brunton L, Barrett K, Hughes R, Torres B, Insel P
Mol Pharmacol
. 2001 Jun;
60(1):26-35.
PMID: 11408597
The P2Y(11) receptor is hypothesized to link to both G(s) and G(q), although this proposition is based on expression and separate assays of G(s) and G(q) function in different cell...
2.
Steinberg S, Brunton L
Annu Rev Pharmacol Toxicol
. 2001 Mar;
41:751-73.
PMID: 11264475
There is a large body of functional data that supports the existence of subcellular compartmentation of the components of cyclic AMP action in the heart. Data from isolated perfused hearts...
3.
Zambon A, Hughes R, Meszaros J, Wu J, Torres B, Brunton L, et al.
Am J Physiol Renal Physiol
. 2000 Nov;
279(6):F1045-52.
PMID: 11097622
Madin-Darby canine kidney (MDCK)-D1 cells, a canine renal epithelial cell line, co-express at least three different P2Y receptor subtypes: P2Y(1), P2Y(2), and P2Y(11) (24). Stimulation of P2Y receptors in these...
4.
Gustafsson A, Brunton L
Mol Pharmacol
. 2000 Nov;
58(6):1470-8.
PMID: 11093787
We have investigated factors modulating expression of inducible NO synthase (iNOS) in isolated adult rat cardiac fibroblasts. Treatment of cardiac fibroblasts with interleukin-1beta (IL-1beta) promotes induction of iNOS mRNA and...
5.
Protein kinase C contributes to desensitization of ANG II signaling in adult rat cardiac fibroblasts
Meszaros J, Raphael R, Lio F, Brunton L
Am J Physiol Cell Physiol
. 2000 Nov;
279(6):C1978-85.
PMID: 11078714
We have studied G(q)-linked ANG II signaling [inositol phosphate (IP) accumulation, Ca(2+) mobilization] in primary cultures of rat cardiac fibroblasts (CFs) and have found that ANG II initiates a protein...
6.
Kanter J, Brunton L
J Mol Cell Cardiol
. 2000 Jun;
32(7):1211-21.
PMID: 10860764
We have developed a high yield technique for isolating ventricular myocytes from adult mouse hearts. This collagenase-trypsin procedure yields 3-6x10(6)cells/heart. The cells are rod-shaped, roughly 20 microM x 100 microM...
7.
Meszaros J, Gonzalez A, Villegas S, Villarreal F, Brunton L
Am J Physiol Cell Physiol
. 2000 Jan;
278(1):C154-62.
PMID: 10644523
Cardiac fibroblasts (CFs) are an important cellular component of myocardial responses to injury and to hypertrophic stimuli. We studied G protein-coupled receptors to understand how CFs integrate signals that activate...
8.
Gustafsson A, Brunton L
Mol Pharmacol
. 1999 Jul;
56(2):377-82.
PMID: 10419557
The fungal metabolite balanol is a potent inhibitor of protein kinase A (PKA) and protein kinase C (PKC) in vitro that acts by competing with ATP for binding (K(i) approximately...
9.
Setyawan J, Koide K, Diller T, Bunnage M, Taylor S, Nicolaou K, et al.
Mol Pharmacol
. 1999 Jul;
56(2):370-6.
PMID: 10419556
Balanol is a potent inhibitor of cyclic AMP-dependent protein kinase and protein kinase C, acting competitively with ATP with an affinity 3000 times that of ATP. We tested the capacity...
10.
Narayana N, Diller T, Koide K, Bunnage M, Nicolaou K, Brunton L, et al.
Biochemistry
. 1999 Feb;
38(8):2367-76.
PMID: 10029530
Endogenous protein kinase inhibitors are essential for a wide range of physiological functions. These endogenous inhibitors may mimic peptide substrates as in the case of the heat-stable protein kinase inhibitor...