L L Brunton
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Explore the profile of L L Brunton including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Martin J, Mestril R, Brunton L, Dillmann W
Circulation
. 1998 Jan;
96(12):4343-8.
PMID: 9416902
Background: Overexpression of the inducible hsp70 protects against ischemic cardiac damage. However, it is unclear whether the small heat shock proteins hsp27 and alphaB-crystallin protect against ischemic injury. Methods And...
12.
Villegas S, Gonzalez A, Brunton L
J Pharmacol Exp Ther
. 1997 Apr;
281(1):267-73.
PMID: 9103506
In experiments on neonatal and adult rat ventricular myocytes, endothelin (ET) binding and the effects of ET on transmembrane signaling are quasi-irreversible. The ET(A) receptor antagonist BQ123 competes for binding...
13.
Ramirez M, Villegas S, Gonzalez A, Brown J, Brunton L
Am J Physiol
. 1997 Jan;
272(1 Pt 2):H130-7.
PMID: 9038931
We have characterized the interaction of endothelin (ET) with cultured neonatal rat ventricular myocytes. Binding studies indicate a single population of ETA receptors [53,000 sites/cell, apparent dissociation constant (Kd) for...
14.
15.
Post S, Urasawa K, Brunton L, Insel P
Biochem J
. 1995 Oct;
311 ( Pt 1):75-80.
PMID: 7575483
We have investigated the stoichiometric relationship of proteins involved in beta-adrenergic-receptor-mediated signal transduction in isolated rat cardiac myocytes. These cells contain about 2.1 x 10(5) beta-adrenergic receptors per cell, as...
16.
Koide K, Bunnage M, Gomez Paloma L, Kanter J, Taylor S, Brunton L, et al.
Chem Biol
. 1995 Sep;
2(9):601-8.
PMID: 9383464
Background: The protein kinase C (PKC) family of serine/threonine-specific protein kinases is involved in many cellular processes, and the unregulated activation of PKC has been implicated in carcinogenesis. PKC inhibitors...
17.
Brunton L
Am J Physiol
. 1995 Sep;
269(3 Pt 2):H798-804.
PMID: 7573520
We have studied the effect of hyposmotic swelling on adenosin 3',5'-cyclic monophosphate (cAMP) metabolism in isolated cardiac myocytes. Decreasing extracellular osmolarity by 12.5-50% results in graded inhibition (10-40%) of isoproterenol-stimulated...
18.
Puceat M, Strulovici B, Brunton L, Brown J
J Biol Chem
. 1994 Jun;
269(24):16938-44.
PMID: 8207017
We have immunologically identified the isoforms of protein kinase C (PKC) present in neonatal and adult rat cardiomyocytes and examined their regulation by hormones and phorbol ester. Both cell types...
19.
Merck D, Lujan J, Brunton L
Mol Pharmacol
. 1994 Jun;
45(6):1183-90.
PMID: 8022411
In adult rat cardiac myocytes, endothelin (ET) receptors couple to multiple signaling pathways, including stimulation of phosphoinositide hydrolysis (pertussis toxin insensitive) and inhibition of adenylyl cyclase via Gi. We have...
20.