L J Mandel
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Explore the profile of L J Mandel including associated specialties, affiliations and a list of published articles.
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120
Citations
1573
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Recent Articles
1.
Chen J, Liu X, Mandel L, Schnellmann R
Toxicol Appl Pharmacol
. 2001 Feb;
171(1):1-11.
PMID: 11181106
The goal of this study was to examine the progression of plasma membrane disruption during cell injury using rabbit renal proximal tubules (RPT). The results demonstrated that the plasma membrane...
2.
DOCTOR R, Chen J, Peters L, Lux S, Mandel L
Am J Physiol
. 1998 Feb;
274(1):F129-38.
PMID: 9458832
In diverse cell types, ankyrin tethers a variety of ion transport and cell adhesion molecules to the spectrin-based membrane skeleton. In the whole kidney, epithelial ankyrin (Ank3) is the predominantly...
3.
Chen J, Mandel L
Am J Physiol
. 1997 Nov;
273(4):C1341-8.
PMID: 9357779
The role of water and electrolyte influxes in anoxia-induced plasma membrane disruption was investigated using rabbit proximal tubule suspension. The results indicated that normal proximal tubule (PT) cells have a...
4.
Chen J, Mandel L
Am J Physiol
. 1997 Aug;
273(2 Pt 1):C710-6.
PMID: 9277369
Because extensive kinase inhibition during anoxia has previously been reported, we investigated the role of kinase inhibition in anoxic cell injury by studying the effects of kinase inhibitors on a...
5.
Derrickson B, Mandel L
Am J Physiol
. 1997 Jun;
272(6 Pt 2):F781-8.
PMID: 9227640
Previous studies from this laboratory have demonstrated that the 3-34 analog of parathyroid hormone (PTH) causes a 15-30% inhibition of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) activity in rat renal proximal tubules through the...
6.
Chen J, Dai J, Grant R, DOCTOR R, Sheetz M, Mandel L
Am J Physiol
. 1997 Apr;
272(4 Pt 1):C1319-28.
PMID: 9142858
The goal of this study was to determine whether anoxic membrane disruption is initiated by loss of cytoskeletal support in rabbit renal proximal tubules (PT). We specifically tested 1) whether...
7.
DOCTOR R, Zhelev D, Mandel L
Am J Physiol
. 1997 Feb;
272(2 Pt 1):C439-49.
PMID: 9124286
Renal ischemia induces cytoskeletal alterations, membrane perturbations, including bleb formation, and ultimately membrane lysis. The mechanisms that underlie these alterations are largely unknown. Through the use of isolated rat renal...
8.
Schonefeld M, Noble S, Bertorello A, Mandel L, Creer M, Portilla D
Kidney Int
. 1996 May;
49(5):1289-96.
PMID: 8731093
We have characterized the effects of hypoxia on carnitine metabolism in proximal tubules. Hypoxia for 10 minutes resulted in a significant increase in the mass of long chain acylcarnitines (LCAC)...
9.
Golenhofen N, DOCTOR R, Bacallao R, Mandel L
Kidney Int
. 1995 Dec;
48(6):1837-45.
PMID: 8587243
ATP-depletion in renal cultured cells has been used as a model for studying various cytoskeletal and functional alterations induced by renal ischemia. This communication explores the reversibility of these effects...
10.
Bhat V, Windridge P, Cherry R, Mandel L
Biotechnol Prog
. 1995 Sep;
11(5):596-600.
PMID: 8546842
The project investigates the relationship between the external shear force and the actin cytoskeleton along with the metabolic changes occurring inside the cells due to this force. Anchorage-dependent Madin Darby...