L G Griffith
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Explore the profile of L G Griffith including associated specialties, affiliations and a list of published articles.
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28
Citations
969
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Recent Articles
1.
Ferrari E, Monti E, Cerutti C, Visone R, Occhetta P, Griffith L, et al.
Biomicrofluidics
. 2023 Dec;
17(6):064103.
PMID: 38058462
The human vasculature is essential in organs and tissues for the transport of nutrients, metabolic waste products, and the maintenance of homeostasis. The integration of vessels in organs-on-chip may, therefore,...
2.
Soenksen L, Kassis T, Noh M, Griffith L, Trumper D
Lab Chip
. 2018 Feb;
18(6):902-914.
PMID: 29437172
Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs...
3.
Tsamandouras N, Kostrzewski T, Stokes C, Griffith L, Hughes D, Cirit M
J Pharmacol Exp Ther
. 2016 Oct;
360(1):95-105.
PMID: 27760784
In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and...
4.
Yu J, Cilfone N, Large E, Sarkar U, Wishnok J, Tannenbaum S, et al.
CPT Pharmacometrics Syst Pharmacol
. 2015 Nov;
4(10):585-94.
PMID: 26535159
Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm. Success will require quantitative...
5.
Sofia S, Kuhl P, Griffith L
Methods Mol Med
. 2011 Mar;
18:19-33.
PMID: 21370164
The immobilization of biomolecules to various supports has been an important research area for many years. Molecules such as heparin (1,2), as well as various enzymes (3,4), antibodies (5,6), and...
6.
Shuga J, Zhang J, Samson L, Lodish H, Griffith L
Proc Natl Acad Sci U S A
. 2007 May;
104(21):8737-42.
PMID: 17502613
The goal of this study was to create an in vitro cell culture system that captures essential features of the in vivo erythroid micronucleus (MN) genotoxicity assay, thus enabling increased...
7.
Sivaraman A, Leach J, Townsend S, Iida T, Hogan B, Stolz D, et al.
Curr Drug Metab
. 2005 Dec;
6(6):569-91.
PMID: 16379670
In vitro models of the liver using isolated primary hepatocytes have been used as screens for measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte proliferation, and as...
8.
Varga C, Tedford N, Thomas M, Klibanov A, Griffith L, Lauffenburger D
Gene Ther
. 2005 Apr;
12(13):1023-32.
PMID: 15815703
An objective of designing molecular vehicles exhibiting virus-like transgene delivery capabilities but with low toxicity and immunogenicity continues to drive synthetic vector development. As no single step within the gene...
9.
Irvine D, Ruzette A, Mayes A, Griffith L
Biomacromolecules
. 2001 Dec;
2(2):545-56.
PMID: 11749219
Part 1 of these studies described poly(methyl methacrylate-r-polyoxyethylene methacrylate) P(MMA-r-POEM) comb polymers that present Arg-Gly-Asp (RGD) peptides at a surface in nanoscale clusters on a protein-resistant background for control of...
10.
Irvine D, Mayes A, Griffith L
Biomacromolecules
. 2001 Dec;
2(1):85-94.
PMID: 11749159
Theoretical and experimental studies were conducted to elucidate the structure and properties of amphiphilic comb polymer thin films presenting nanoscale clusters of Arg-Gly-Asp (RGD) peptides for control of cell adhesion...