L E Limbird
Overview
Explore the profile of L E Limbird including associated specialties, affiliations and a list of published articles.
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Articles
107
Citations
1666
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Recent Articles
1.
Lu R, Chen Y, Cottingham C, Peng N, Jiao K, Limbird L, et al.
Mol Pharmacol
. 2010 May;
78(2):279-86.
PMID: 20430865
We previously identified spinophilin as a regulator of alpha(2) adrenergic receptor (alpha(2)AR) trafficking and signaling in vitro and in vivo (Science 304:1940-1944, 2004). To assess the generalized role of spinophilin...
2.
Zhang Y, Limbird L
Biochem Soc Trans
. 2004 Oct;
32(Pt 5):856-60.
PMID: 15494033
Complexes of alpha(2A)-ARs (alpha(2A)-adrenergic receptors) and MORs (mu-opioid receptors), probably hetero-oligomers, were detected by co-immunoisolation after extraction from HEK-293 cells (human embryonic kidney 293 cells). Functional communication between these receptors...
3.
Schramm N, McDonald M, Limbird L
J Neurosci
. 2001 Jun;
21(13):4875-82.
PMID: 11425914
The noradrenergic system is involved in the regulation of many physiological and psychological processes, including the modulation of mood. The alpha(2)-adrenergic receptors (alpha(2)-ARs) modulate norepinephrine release, as well as the...
4.
Wilson M, Highfield H, Limbird L
Mol Pharmacol
. 2001 Mar;
59(4):929-38.
PMID: 11259639
Functional and structural data from G protein-coupled receptors (GPCR) predict that transmembrane-domain (TM)2 is adjacent to TM7 within the GPCR structure, and that within this interface a conserved aspartate in...
5.
Richman J, Brady A, Wang Q, Hensel J, Colbran R, Limbird L
J Biol Chem
. 2001 Jan;
276(18):15003-8.
PMID: 11154706
Previously, we demonstrated that the third intracellular (3i) loop of the heptahelical alpha2A-adrenergic receptor (alpha2A AR) is critical for retention at the basolateral surface of polarized Madin-Darby canine kidney II...
6.
Edwards S, Tan C, Limbird L
Trends Pharmacol Sci
. 2000 Aug;
21(8):304-8.
PMID: 10918636
G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The...
7.
Holmes E, Burks T, Dzau V, Hindery M, Jones R, Kaye C, et al.
Acad Med
. 2000 Mar;
75(3):303-13.
PMID: 10724325
The authors of this article, who were the members and staff of a research panel formed by the AAMC as part of its mission-based management initiative, reflect on the growing...
8.
McDuffie J, Motley E, Limbird L, Maleque M
J Cardiovasc Pharmacol
. 2000 Mar;
35(3):398-402.
PMID: 10710124
5-Hydroxytryptamine (5-HT) is sequestered and released by endothelial cells, acts as an endothelial cell mitogen, promotes the release of nitric oxide (NO), and has been associated with the p44/p42 mitogen-activated...
9.
Wilson M, Limbird L
Biochemistry
. 2000 Jan;
39(4):693-700.
PMID: 10651634
Despite considerable insights concerning the mechanisms regulating short-term agonist-mediated G protein-coupled receptor (GPCR) internalization, little is known about the mechanisms regulating GPCR surface residence over long periods of time. Herein,...
10.
Saunders C, Limbird L
Mol Pharmacol
. 2000 Jan;
57(1):44-52.
PMID: 10617677
Previous studies in cultured, polarized Madin-Darby canine kidney II (MDCKII) renal epithelial cells have demonstrated that the apical steady-state localization and delivery of the A(1) adenosine receptor is modified by...