L E Heasley
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Explore the profile of L E Heasley including associated specialties, affiliations and a list of published articles.
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54
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1503
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Recent Articles
11.
Schwertfeger K, Hunter S, Heasley L, Levresse V, Leon R, DeGregori J, et al.
Mol Endocrinol
. 2000 Oct;
14(10):1592-602.
PMID: 11043575
In recent years the mitogen-activated protein (MAP) kinase family has expanded to include both c-jun N-terminal kinases (JNKs), and the p38/HOG1 family in addition to the extracellular regulated kinase (ERK)...
12.
Van Putten V , Refaat Z, Dessev C, Blaine S, Wick M, Butterfield L, et al.
J Biol Chem
. 2000 Oct;
276(2):1226-32.
PMID: 11042196
Mutations in ras genes have been detected with high frequency in nonsmall cell lung cancer cells (NSCLC) and contribute to transformed growth of these cells. It has previously been shown...
13.
Zhang T, Gealy R, Lu X, Heasley L, Takimoto K, Levitan E
Mol Cell Endocrinol
. 2000 Aug;
165(1-2):33-9.
PMID: 10940481
Thyrotropin-releasing hormone (TRH) decreases transcription of the Kv1.5 K(+) channel gene in GH(3) pituitary cells. Here, we examine whether TRH utilizes Gq activated phospholipase C, Gs or Gi to produce...
14.
Yang T, Huang Y, Heasley L, Berl T, Schnermann J, Briggs J
J Biol Chem
. 2000 Aug;
275(30):23281-6.
PMID: 10930430
We have previously shown that hypertonicity stimulates cyclooxygenase-2 (COX-2) expression in cultured medullary epithelial cells. The aims of the present study were (i) to examine the role of cytoplasmic signaling...
15.
Soriano A, Helfrich B, Chan D, Heasley L, Bunn Jr P, Chou T
Cancer Res
. 2000 Jan;
59(24):6178-84.
PMID: 10626810
Non-small cell lung cancer (NSCLC) cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX) 2. These NSCLC cells also have increased prostaglandin expression (PGE2). Many lung...
16.
Butterfield L, Zentrich E, Beekman A, Heasley L
Biochem J
. 1999 Mar;
338 ( Pt 3):681-6.
PMID: 10051439
The cJun N-terminal kinases (JNKs) are encoded by three genes generating ten protein kinase polypeptides and are activated in settings of cell stress, mitogenesis, differentiation and morphogenesis. The specific role...
17.
In vivo regulation of MAP kinases in Ratus norvegicus renal papilla by water loading and restriction
Wojtaszek P, Heasley L, Berl T
J Clin Invest
. 1998 Nov;
102(10):1874-81.
PMID: 9819374
In cultured renal cells, hypertonicity activates multiple mitogen-activated protein kinases (MAPKs) and enhances the expression of heat shock proteins (HSPs). In rats, 24 h water restriction increased mean urinary osmolality...
18.
Li X, Van Putten V, Zarinetchi F, Nicks M, Thaler S, Heasley L, et al.
Biochem J
. 1998 May;
327 ( Pt 3):709-16.
PMID: 9581546
Platelet-derived growth factor (PDGF), which is a potent mitogen for vascular smooth-muscle cells (VSMC), also inhibits the expression of specific smooth-muscle proteins, including smooth-muscle alpha-actin (SM-alpha-actin), in these cells. The...
19.
Beekman A, Helfrich B, Bunn Jr P, Heasley L
Cancer Res
. 1998 Mar;
58(5):910-3.
PMID: 9500449
Transformed growth of human small cell lung cancer (SCLC) is mediated by autocrine signaling through multiple G protein-coupled neuropeptide receptors. To define the role of Gq and its effector, phospholipase...
20.
Wojtaszek P, Heasley L, Siriwardana G, Berl T
J Biol Chem
. 1998 Feb;
273(2):800-4.
PMID: 9422734
The c-Jun NH2-terminal protein kinases (JNKs), as well as the extracellular signal-regulated protein kinases (ERKs) and p38 mitogen-activated protein kinase, are activated in renal cells in response to extracellular hypertonicity....