L E BIRD
Overview
Explore the profile of L E BIRD including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
600
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0
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Recent Articles
1.
Ren J, BIRD L, Chamberlain P, Stewart-Jones G, Stuart D, Stammers D
Proc Natl Acad Sci U S A
. 2002 Oct;
99(22):14410-5.
PMID: 12386343
The HIV-2 serotype of HIV is a cause of disease in parts of the West African population, and there is evidence for its spread to Europe and Asia. HIV-2 reverse...
2.
Ren J, Nichols C, BIRD L, Fujiwara T, Sugimoto H, Stuart D, et al.
J Biol Chem
. 2000 May;
275(19):14316-20.
PMID: 10799511
S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to...
3.
Ren J, Diprose J, Warren J, Esnouf R, BIRD L, Ikemizu S, et al.
J Biol Chem
. 2000 Feb;
275(8):5633-9.
PMID: 10681546
Most non-nucleoside reverse transcriptase (RT) inhibitors are specific for HIV-1 RT and demonstrate minimal inhibition of HIV-2 RT. However, we report that members of the phenylethylthiazolylthiourea (PETT) series of non-nucleoside...
4.
BIRD L, Pan H, Soultanas P, Wigley D
Biochemistry
. 2000 Jan;
39(1):171-82.
PMID: 10625492
For the first time, we demonstrate directly a stable complex between a bacterial DnaG (primase) and DnaB (helicase). Utilizing fragments of both proteins, we are able to dissect interactions within...
5.
Pan H, BIRD L, Wigley D
Biochim Biophys Acta
. 1999 Mar;
1444(3):429-33.
PMID: 10095067
The dnaG gene encoding DNA primase has been isolated from chromosomal DNA of Bacillus stearothermophilus and its entire nucleotide sequence determined. The deduced amino acid sequence comprised 597 amino acid...
6.
BIRD L, Wigley D
Biochim Biophys Acta
. 1999 Mar;
1444(3):424-8.
PMID: 10095066
As part of biochemical and structural studies of the primosome of a gram positive bacterial species, we describe the cloning of the Bacillus stearothermophilus replicative helicase, DnaB. The protein is...
7.
BIRD L, Brannigan J, Subramanya H, Wigley D
Nucleic Acids Res
. 1998 May;
26(11):2686-93.
PMID: 9592155
PcrA from Bacillus stearothermophilus is a DNA helicase for which, despite the availability of a crystal structure, there is very little biochemical information. We show that the enzyme has a...
8.
BIRD L, Subramanya H, Wigley D
Curr Opin Struct Biol
. 1998 Mar;
8(1):14-8.
PMID: 9519291
The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical...
9.
Subramanya H, Arciszewska L, Baker R, BIRD L, Sherratt D, Wigley D
EMBO J
. 1997 Oct;
16(17):5178-87.
PMID: 9311978
The structure of the site-specific recombinase, XerD, that functions in circular chromosome separation, has been solved at 2.5 A resolution and reveals that the protein comprises two domains. The C-terminal...
10.
BIRD L, Hakansson K, Pan H, Wigley D
Nucleic Acids Res
. 1997 Jul;
25(13):2620-6.
PMID: 9185573
Limited proteolysis of bacteriophage T7 primase/helicase with endoproteinase Glu-C produces several proteolytic fragments. One of these fragments, which is derived from the C-terminal region of the protein, was prepared and...