Helicases: a Unifying Structural Theme?

Overview

Journal Curr Opin Struct Biol

Date 1998 Mar 31

PMID 9519291

Citations 54

Authors

L E BIRD

H S Subramanya

D B Wigley

Affiliations

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Abstract

The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical analyses, as well as microscopy studies of hexameric helicases, a picture of a unifying structure and mechanism for all helicases is beginning to emerge.

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