Kyle J Travaglini
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Explore the profile of Kyle J Travaglini including associated specialties, affiliations and a list of published articles.
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1836
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Recent Articles
1.
Miller J, Travaglini K, Luquez T, Hostetler R, Oster A, Daniel S, et al.
bioRxiv
. 2025 Feb;
PMID: 39990500
Single-cell multiomic technologies have allowed unprecedented access to gene profiles of individual cells across species and organ systems, including >1000 papers focused on brain cell types alone. The Allen Institute...
2.
Gabitto M, Travaglini K, Rachleff V, Kaplan E, Long B, Ariza J, et al.
Nat Neurosci
. 2024 Oct;
27(12):2366-2383.
PMID: 39402379
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we...
3.
Hawrylycz M, Kaplan E, Travaglini K, Gabitto M, Miller J, Ng L, et al.
Nat Aging
. 2024 Oct;
4(10):1331-1334.
PMID: 39402332
No abstract available.
4.
Agrawal A, Rachleff V, Travaglini K, Mukherjee S, Crane P, Hawrylycz M, et al.
bioRxiv
. 2024 Jun;
PMID: 38915664
Throughout an organism's life, a multitude of complex and interdependent biological systems transition through biophysical processes that serve as indicators of the underlying biological states. Inferring these latent, unobserved states...
5.
Emani P, Liu J, Clarke D, Jensen M, Warrell J, Gupta C, et al.
Science
. 2024 May;
384(6698):eadi5199.
PMID: 38781369
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly...
6.
Wu T, Travaglini K, Rustagi A, Xu D, Zhang Y, Andronov L, et al.
J Exp Med
. 2024 Apr;
221(6.
PMID: 38597954
Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus by productively infecting healthy human...
7.
Emani P, Liu J, Clarke D, Jensen M, Warrell J, Gupta C, et al.
bioRxiv
. 2024 Apr;
PMID: 38562822
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet, little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly...
8.
Jorstad N, Close J, Johansen N, Yanny A, Barkan E, Travaglini K, et al.
Science
. 2023 Oct;
382(6667):eadf6812.
PMID: 37824655
Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We used single cell transcriptomics and performed cellular characterization of the human cortex to better understand cortical...
9.
Johansen N, Somasundaram S, Travaglini K, Yanny A, Shumyatcher M, Casper T, et al.
Science
. 2023 Oct;
382(6667):eadf2359.
PMID: 37824649
Single-cell transcriptomic studies have identified a conserved set of neocortical cell types from small postmortem cohorts. We extended these efforts by assessing cell type variation across 75 adult individuals undergoing...
10.
Jorstad N, Song J, Exposito-Alonso D, Suresh H, Castro-Pacheco N, Krienen F, et al.
Science
. 2023 Oct;
382(6667):eade9516.
PMID: 37824638
The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics to analyze samples of the middle temporal...