Kwong Tai Cheng
Overview
Explore the profile of Kwong Tai Cheng including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
19
Citations
1358
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0
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Recent Articles
1.
Osei-Amponsa V, Sridharan V, Tandon M, Evans C, Klarmann K, Cheng K, et al.
Mol Cell Biol
. 2020 Jul;
40(18).
PMID: 32631902
hRpn13/ADRM1 links substrate recruitment with deubiquitination at the proteasome through its proteasome- and ubiquitin-binding Pru domain and DEUBAD domain, which binds and activates deubiquitinating enzyme (DUB) UCHL5/Uch37. Here, we edit...
2.
Ye Z, Zhang L, Li R, Dong W, Liu S, Li Z, et al.
Kidney Blood Press Res
. 2019 Jun;
44(4):465-478.
PMID: 31230050
Background/aims: Acute kidney injury (AKI) is a serious complication of sepsis and has a high morbidity and mortality rate. Caspase-11 induces pyroptosis, a form of programmed cell death that plays...
3.
Talsania K, Mehta M, Raley C, Kriga Y, Gowda S, Grose C, et al.
Genes (Basel)
. 2019 Jan;
10(2).
PMID: 30678108
Background: derived cell lines are commonly used to enable recombinant protein expression via baculovirus infection to generate materials approved for clinical use and in clinical trials. In order to develop...
4.
Yuan T, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, et al.
Cell Rep
. 2018 Feb;
22(7):1889-1902.
PMID: 29444439
KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3' kinase, and RalGDS families, but many additional direct and indirect effectors...
5.
Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al.
J Clin Invest
. 2017 Oct;
127(11):4124-4135.
PMID: 28990935
Acute lung injury is a leading cause of death in bacterial sepsis due to the wholesale destruction of the lung endothelial barrier, which results in protein-rich lung edema, influx of...
6.
Tsang K, Hyun J, Cheng K, Vargas M, Mehta D, Ushio-Fukai M, et al.
Stem Cell Reports
. 2017 Aug;
9(3):796-806.
PMID: 28781077
The generation of functional arterial endothelial cells (aECs) from embryonic stem cells (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of...
7.
Liu X, Gong B, de Souza L, Ong H, Subedi K, Cheng K, et al.
Sci Signal
. 2017 Jun;
10(482).
PMID: 28588080
Store-operated Ca entry (SOCE) is critical for salivary gland fluid secretion. We report that radiation treatment caused persistent salivary gland dysfunction by activating a TRPM2-dependent mitochondrial pathway, leading to caspase-3-mediated...
8.
Ong H, de Souza L, Zheng C, Cheng K, Liu X, Goldsmith C, et al.
Sci Signal
. 2015 Jan;
8(359):ra3.
PMID: 25587190
A central component of receptor-evoked Ca(2+) signaling is store-operated Ca(2+) entry (SOCE), which is activated by the assembly of STIM1-Orai1 channels in endoplasmic reticulum (ER) and plasma membrane (PM) (ER-PM)...
9.
Ong H, de Souza L, Cheng K, Ambudkar I
Handb Exp Pharmacol
. 2014 Jun;
223:1005-34.
PMID: 24961978
The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1-TRPC7), are Ca(2+)-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels...
10.
Cheng K, Ong H, Liu X, Ambudkar I
Curr Top Membr
. 2013 Jul;
71:149-79.
PMID: 23890115
Store-operated calcium entry (SOCE) is activated in response to depletion of the endoplasmic reticulum-Ca(2+) stores following stimulation of plasma membrane receptors that couple to PIP2 hydrolysis and IP3 generation. Search...