Kutlu G Elpek
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Explore the profile of Kutlu G Elpek including associated specialties, affiliations and a list of published articles.
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21
Citations
2995
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Recent Articles
1.
Platzer B, Elpek K, Cremasco V, Baker K, Stout M, Schultz C, et al.
Cell Rep
. 2015 Mar;
10(9):1487-1495.
PMID: 25753415
Epidemiologic studies discovered an inverse association between immunoglobulin E (IgE)-mediated allergies and cancer, implying tumor-protective properties of IgE. However, the underlying immunologic mechanisms remain poorly understood. Antigen cross-presentation by dendritic...
2.
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, et al.
Nat Med
. 2014 Dec;
21(1):71-5.
PMID: 25485910
Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate...
3.
Elpek K, Cremasco V, Shen H, Harvey C, Wucherpfennig K, Goldstein D, et al.
Cancer Immunol Res
. 2014 May;
2(7):655-67.
PMID: 24801837
Myeloid cells play important regulatory roles within the tumor environment by directly promoting tumor progression and modulating the function of tumor-infiltrating lymphocytes, and as such, they represent a potential therapeutic...
4.
Gautier E, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, et al.
Nat Immunol
. 2012 Oct;
13(11):1118-28.
PMID: 23023392
We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were...
5.
Acton S, Astarita J, Malhotra D, Lukacs-Kornek V, Franz B, Hess P, et al.
Immunity
. 2012 Aug;
37(2):276-89.
PMID: 22884313
To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN). PDPN is expressed by lymphatic...
6.
Miller J, Brown B, Shay T, Gautier E, Jojic V, Cohain A, et al.
Nat Immunol
. 2012 Jul;
13(9):888-99.
PMID: 22797772
Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs...
7.
Malhotra D, Fletcher A, Astarita J, Lukacs-Kornek V, Tayalia P, F Gonzalez S, et al.
Nat Immunol
. 2012 Apr;
13(5):499-510.
PMID: 22466668
Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly elucidated. Here, comparative transcriptomic analyses of mouse LNSC subsets demonstrated the expression...
8.
Ying H, Elpek K, Vinjamoori A, Zimmerman S, Chu G, Yan H, et al.
Cancer Discov
. 2011 Oct;
1(2):158-69.
PMID: 21984975
Initiation of pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic KRAS mutation, and disease progression is associated with frequent loss of tumor suppressors. In this study, human PDAC genome analyses...
9.
Lukacs-Kornek V, Malhotra D, Fletcher A, Acton S, Elpek K, Tayalia P, et al.
Nat Immunol
. 2011 Sep;
12(11):1096-104.
PMID: 21926986
Fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) are nonhematopoietic stromal cells of lymphoid organs. They influence the migration and homeostasis of naive T cells; however, their influence on...
10.
Elpek K, Bellemare-Pelletier A, Malhotra D, Reynoso E, Lukacs-Kornek V, DeKruyff R, et al.
PLoS One
. 2011 Sep;
6(8):e23921.
PMID: 21886840
Lymphoid organ-resident DC subsets are thought to play unique roles in determining the fate of T cell responses. Recent studies focusing on a single lymphoid organ identified molecular pathways that...