Haval Shirwan
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Explore the profile of Haval Shirwan including associated specialties, affiliations and a list of published articles.
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Articles
88
Citations
1487
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Recent Articles
1.
Ramos-Gonzalez M, Natesh N, Rachagani S, Amos-Landgraf J, Shirwan H, Yolcu E, et al.
Int J Mol Sci
. 2024 Oct;
25(19).
PMID: 39408747
Luciferase (luc) bioluminescence (BL) is the most used light-emitting protein that has been engineered to be expressed in multiple cancer cell lines, allowing for the detection of tumor nodules in...
2.
Grattoni A, Korbutt G, Tomei A, Garcia A, Pepper A, Stabler C, et al.
Nat Rev Endocrinol
. 2024 Sep;
21(1):14-30.
PMID: 39227741
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading...
3.
Turan A, Tarique M, Zhang L, Kazmi S, Ulker V, Tedla M, et al.
J Immunol
. 2024 May;
212(12):1971-1980.
PMID: 38709159
Most pancreatic islets are destroyed immediately after intraportal transplantation by an instant blood-mediated inflammatory reaction (IBMIR) generated through activation of coagulation, complement, and proinflammatory pathways. Thus, effective mitigation of IBMIR...
4.
Ramos-Gonzalez M, Tarique M, Batra L, Arguc F, Garza-Morales R, Shirwan H, et al.
Vaccines (Basel)
. 2024 Mar;
12(3).
PMID: 38543974
Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8 T cells. We reported the generation of an active soluble oligomeric construct,...
5.
Racca N, Dontu A, Riley K, Yolcu E, Shirwan H, Coronel M
Tissue Eng Part A
. 2024 Feb;
30(7-8):299-313.
PMID: 38318841
Immune checkpoint signaling, such as programmed cell death protein-1 (PD-1), is a key target for immunotherapy due to its role in dampening immune responses. PD-1 signaling in T cells is...
6.
Tedla M, Wright N, Yolcu E, Wang Y, Shirwan H
STAR Protoc
. 2024 Jan;
5(1):102816.
PMID: 38180833
Although the male epididymal fat pad is an effective site for islet transplantation, females lack this tissue. Here, we present a protocol to assess the parametrial fat pad (PFP) adjacent...
7.
Gulen A, Rudraboina R, Tarique M, Ulker V, Shirwan H, Yolcu E
Cancer Immunol Immunother
. 2023 Aug;
72(11):3567-3579.
PMID: 37605009
Immunotherapy utilizing checkpoint inhibitors has shown remarkable success in the treatment of cancers. In addition to immune checkpoint inhibitors, immune co-stimulation has the potential to enhance immune activation and destabilize...
8.
Coronel M, Linderman S, Martin K, Hunckler M, Medina J, Barber G, et al.
Am J Transplant
. 2023 Aug;
23(11):1709-1722.
PMID: 37543091
The induction of operational immune tolerance is a major goal in beta-cell replacement strategies for the treatment of type 1 diabetes. Our group previously reported long-term efficacy via biomaterial-mediated programmed...
9.
Turan A, Zhang L, Tarique M, Ulker V, Arguc F, Badal D, et al.
Am J Transplant
. 2023 Mar;
23(5):619-628.
PMID: 36863480
The instant blood-mediated inflammatory reaction (IBMIR) is initiated by innate immune responses that cause substantial islet loss after intraportal transplantation. Thrombomodulin (TM) is a multifaceted innate immune modulator. In this...
10.
Deng H, Zhang A, Pang D, Xi Y, Yang Z, Matheson R, et al.
Cell Rep Med
. 2023 Mar;
4(3):100959.
PMID: 36863336
The transplanting islets to the liver approach suffers from an immediate posttransplant loss of islets of more than 50%, progressive graft dysfunction over time, and precludes recovery of grafts should...