Deciphering the Transcriptional Network of the Dendritic Cell Lineage

Overview

Journal Nat Immunol

Date 2012 Jul 17

PMID 22797772

Citations 411

Authors

Jennifer C Miller

Brian D Brown

Tal Shay

Emmanuel L Gautier

Vladimir Jojic

Ariella Cohain

Gaurav Pandey

Marylene Leboeuf

Kutlu G Elpek

Julie Helft

Daigo Hashimoto

Andrew Chow

Jeremy Price

Melanie Greter

Milena Bogunovic

Angelique Bellemare-Pelletier

Paul S Frenette

Gwendalyn J Randolph

Shannon J Turley

Miriam Merad

Affiliations

Soon will be listed here.

Abstract

Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made a comprehensive comparative analysis of CD8(+), CD103(+), CD11b(+) and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized candidate transcriptional activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted regulators of DC functional diversity in tissues. We identified a molecular signature that distinguished tissue DCs from macrophages. We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens.

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