Kurt Drickamer
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Explore the profile of Kurt Drickamer including associated specialties, affiliations and a list of published articles.
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65
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2180
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Recent Articles
11.
Zheng R, Jegouzo S, Joe M, Bai Y, Tran H, Shen K, et al.
ACS Chem Biol
. 2017 Oct;
12(12):2990-3002.
PMID: 29048873
An array of homogeneous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis and other mycobacteria has been probed with a...
12.
Feinberg H, Jegouzo S, Rex M, Drickamer K, Weis W, Taylor M
J Biol Chem
. 2017 Jun;
292(32):13402-13414.
PMID: 28652405
Dectin-2, a C-type lectin on macrophages and other cells of the innate immune system, functions in response to pathogens, particularly fungi. The carbohydrate-recognition domain (CRD) in dectin-2 is linked to...
13.
PrabhuDas M, Baldwin C, Bollyky P, Bowdish D, Drickamer K, Febbraio M, et al.
J Immunol
. 2017 May;
198(10):3775-3789.
PMID: 28483986
Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and...
14.
Dos Santos A, Hadjivasiliou A, Ossa F, Lim N, Turgut A, Taylor M, et al.
Protein Sci
. 2016 Nov;
26(2):306-316.
PMID: 27859859
Human dendritic cell-specific intercellular adhesion molecule-1 grabbing nonintegrin, DC-SIGN, and the sinusoidal endothelial cell receptor DC-SIGNR or L-SIGN, are closely related sugar-binding receptors. DC-SIGN acts both as a pathogen-binding endocytic...
15.
Feinberg H, Rambaruth N, Jegouzo S, Jacobsen K, Djurhuus R, Poulsen T, et al.
J Biol Chem
. 2016 Aug;
291(40):21222-21233.
PMID: 27542410
The macrophage receptor mincle binds to trehalose dimycolate on the surface of Mycobacterium tuberculosis Signaling initiated by this interaction leads to cytokine production, which underlies the ability of mycobacteria to...
16.
Breiman A, Lopez Robles M, de Carne Trecesson S, Echasserieau K, Bernardeau K, Drickamer K, et al.
Oncotarget
. 2016 Feb;
7(12):14064-82.
PMID: 26908442
Terminal fucosylated motifs of glycoproteins and glycolipid chains are often altered in cancer cells. We investigated the link between fucosylation changes and critical steps in cancer progression: epithelial-to-mesenchymal transition (EMT)...
17.
Drickamer K, Taylor M
Curr Opin Struct Biol
. 2015 Jul;
34:26-34.
PMID: 26163333
The majority of the C-type lectin-like domains in the human genome likely to bind sugars have been investigated structurally, although novel mechanisms of sugar binding are still being discovered. In...
18.
Jegouzo S, Feinberg H, Dungarwalla T, Drickamer K, Weis W, Taylor M
J Biol Chem
. 2015 May;
290(27):16759-71.
PMID: 25995448
Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these...
19.
Jacobsen K, Keiding U, Clement L, Schaffert E, Rambaruth N, Johannsen M, et al.
Medchemcomm
. 2015 Apr;
6(4):647-652.
PMID: 25893085
We demonstrate that the natural product brartemicin, a newly discovered inhibitor of cancer cell invasion, is a high-affinity ligand of the carbohydrate-recognition domain (CRD) of the C-type lectin mincle. Recent...
20.
Rambaruth N, Jegouzo S, Marlor H, Taylor M, Drickamer K
Molecules
. 2015 Apr;
20(4):6670-82.
PMID: 25884549
Mincle, the macrophage-inducible C-type lectin also known as CLEC-4E, binds to the mycobacterial glycolipid trehalose dimycolate and initiates a signaling cascade by serving as a receptor for Mycobacterium tuberculosis and...