Kuppusamy Balamurugan
Overview
Explore the profile of Kuppusamy Balamurugan including associated specialties, affiliations and a list of published articles.
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25
Citations
1125
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Recent Articles
1.
Sengodan S, Hu X, Peddibhotla V, Balamurugan K, Mitrophanov A, McKennett L, et al.
J Clin Invest
. 2024 Jan;
134(7).
PMID: 38271119
Loss of BRCA2 (breast cancer 2) is lethal for normal cells. Yet it remains poorly understood how, in BRCA2 mutation carriers, cells undergoing loss of heterozygosity overcome the lethality and...
2.
Balamurugan K, Poria D, Sehareen S, Krishnamurthy S, Tang W, McKennett L, et al.
JCI Insight
. 2023 Feb;
8(6).
PMID: 36757813
Metastatic progression of epithelial cancers can be associated with epithelial-mesenchymal transition (EMT) including transcriptional inhibition of E-cadherin (CDH1) expression. Recently, EM plasticity (EMP) and E-cadherin-mediated, cluster-based metastasis and treatment resistance...
3.
Sheshadri N, Poria D, Sharan S, Hu Y, Yan C, Koparde V, et al.
Cell Death Dis
. 2021 Nov;
12(11):1038.
PMID: 34725321
Cancer cells experience endoplasmic reticulum (ER) stress due to activated oncogenes and conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response (UPR) is executed by ATF6, IRE1 and...
4.
Gale Jr M, Savan R, Garcia-Sastre A, Prokunina-Olsso L, Balamurugan K, Young H
J Interferon Cytokine Res
. 2021 May;
41(5):161-163.
PMID: 34003679
No abstract available.
5.
Poria D, Sheshadri N, Balamurugan K, Sharan S, Sterneck E
J Biol Chem
. 2021 Apr;
296:100220.
PMID: 33839684
Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor involved in many physiological functions including embryonic development and immune responses and is often activated under pathological...
6.
Saxena K, Jolly M, Balamurugan K
Transl Oncol
. 2020 Aug;
13(11):100845.
PMID: 32781367
Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT also confers properties such as stemness, drug resistance...
7.
Sterneck E, Poria D, Balamurugan K
Front Mol Biosci
. 2020 Aug;
7:138.
PMID: 32760736
During physiological epithelial-mesenchymal transition (EMT), which is important for embryogenesis and wound healing, epithelial cells activate a program to remodel their structure and achieve a mesenchymal fate. In cancer cells,...
8.
Balamurugan K, Mendoza-Villanueva D, Sharan S, Summers G, Dobrolecki L, Lewis M, et al.
Oncogene
. 2018 Sep;
38(20):3765-3780.
PMID: 30262865
To improve cancer patient outcome significantly, we must understand the mechanisms regulating stem-like cancer cells, which have been implicated as a cause of metastasis and treatment resistance. The transcription factor...
9.
Balamurugan K
Int J Cancer
. 2015 Mar;
138(5):1058-66.
PMID: 25784597
The complex cross-talk of intricate intercellular signaling networks between the tumor and stromal cells promotes cancer progression. Hypoxia is one of the most common conditions encountered within the tumor microenvironment...
10.
Balamurugan K, Sterneck E
Int J Biol Sci
. 2013 Oct;
9(9):917-33.
PMID: 24155666
The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ) is a transcription factor that modulates many biological processes including cell differentiation, motility, growth arrest, proliferation, and cell death. The diversity of C/EBPδ's...