Kung-Yen Chang
Overview
Explore the profile of Kung-Yen Chang including associated specialties, affiliations and a list of published articles.
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14
Citations
804
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Recent Articles
1.
Xiong X, Kurthkoti K, Chang K, Li J, Ren X, Ni J, et al.
PLoS Pathog
. 2016 Nov;
12(11):e1006034.
PMID: 27893816
microRNAs are endogenous small regulatory RNAs that modulate myriad biological processes by repressing target gene expression in a sequence-specific manner. Here we show that the conserved miRNA miR-34 regulates innate...
2.
Han T, Yang C, Chang K, Zhang D, Imam F, Rana T
EMBO Rep
. 2016 Nov;
17(12):1814-1828.
PMID: 27797851
Hematopoietic stem cells (HSCs) are capable of giving rise to all blood cell lineages throughout adulthood, and the generation of engraftable HSCs from human pluripotent stem cells is a major...
3.
Zhou Y, Dang J, Chang K, Yau E, Aza-Blanc P, Moscat J, et al.
Cancer Res
. 2016 Oct;
76(19):5777-5787.
PMID: 27698189
Global miRNA functional screens can offer a strategy to identify synthetic lethal interactions in cancer cells that might be exploited therapeutically. In this study, we applied this strategy to identify...
4.
Yang C, Chang K, Dang J, Rana T
Sci Rep
. 2016 Jun;
6:26899.
PMID: 27247273
The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical roles in the epigenetic modulation of gene expression. Here, we show that the PRC1 component polycomb group...
5.
Li Z, Dang J, Chang K, Rana T
RNA
. 2014 Oct;
20(12):1900-15.
PMID: 25336587
Somatic cells can be reprogrammed to reach an embryonic stem cell-like state by overexpression of defined factors. Recent studies have greatly improved the efficiency of the reprogramming process but the...
6.
Yang C, Chang K, Rana T
Cell Rep
. 2014 Jul;
8(2):327-37.
PMID: 25043178
Although transcriptome analysis can uncover the molecular changes that occur during induced reprogramming, the functional requirements for a given factor during stepwise cell-fate transitions are left unclear. Here, we used...
7.
Sakurai K, Talukdar I, Patil V, Dang J, Li Z, Chang K, et al.
Cell Stem Cell
. 2014 Apr;
14(4):523-34.
PMID: 24702998
The creation of induced pluripotent stem cells (iPSCs) from somatic cells by ectopic expression of transcription factors has galvanized the fields of regenerative medicine and developmental biology. Here, we report...
8.
Lin N, Chang K, Li Z, Gates K, Rana Z, Dang J, et al.
Mol Cell
. 2014 Feb;
53(6):1005-19.
PMID: 24530304
Here, we generated a genome-scale shRNA library targeting long intergenic noncoding RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function study in mouse embryonic stem cells (mESCs) and identified...
9.
Henzler C, Li Z, Dang J, Arcila M, Zhou H, Liu J, et al.
Genome Biol
. 2014 Jan;
14(12):R149.
PMID: 24380417
Background: MiRNAs often operate in feedback loops with transcription factors and represent a key mechanism for fine-tuning gene expression. In transcription factor-induced reprogramming, miRNAs play a critical role; however, detailed...
10.
Li Z, Chao T, Chang K, Lin N, Patil V, Shimizu C, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
111(3):1002-7.
PMID: 24371310
Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, we used...