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Chao-Shun Yang

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Articles 18
Citations 733
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Recent Articles
1.
Han T, Yang C, Chang K, Zhang D, Imam F, Rana T
EMBO Rep . 2016 Nov; 17(12):1814-1828. PMID: 27797851
Hematopoietic stem cells (HSCs) are capable of giving rise to all blood cell lineages throughout adulthood, and the generation of engraftable HSCs from human pluripotent stem cells is a major...
2.
Yang C, Chang K, Dang J, Rana T
Sci Rep . 2016 Jun; 6:26899. PMID: 27247273
The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical roles in the epigenetic modulation of gene expression. Here, we show that the PRC1 component polycomb group...
3.
Yang C, Chang K, Rana T
Cell Rep . 2014 Jul; 8(2):327-37. PMID: 25043178
Although transcriptome analysis can uncover the molecular changes that occur during induced reprogramming, the functional requirements for a given factor during stepwise cell-fate transitions are left unclear. Here, we used...
4.
Sakurai K, Talukdar I, Patil V, Dang J, Li Z, Chang K, et al.
Cell Stem Cell . 2014 Apr; 14(4):523-34. PMID: 24702998
The creation of induced pluripotent stem cells (iPSCs) from somatic cells by ectopic expression of transcription factors has galvanized the fields of regenerative medicine and developmental biology. Here, we report...
5.
Lin N, Chang K, Li Z, Gates K, Rana Z, Dang J, et al.
Mol Cell . 2014 Feb; 53(6):1005-19. PMID: 24530304
Here, we generated a genome-scale shRNA library targeting long intergenic noncoding RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function study in mouse embryonic stem cells (mESCs) and identified...
6.
Yang C, Rana T
Mol Biosyst . 2012 Oct; 9(1):10-7. PMID: 23037570
Induced reprogramming of somatic cells has had a great impact on stem cell research, and the reprogramming technologies have evolved from four transgenic factors (Oct4, Sox2, Klf4, and c-Myc; OSKM)...
7.
Yang C, Lopez C, Rana T
Stem Cells . 2011 Sep; 29(10):1528-36. PMID: 21898684
Recent breakthroughs in creating induced pluripotent stem cells (iPSCs) provide alternative means to obtain embryonic stem-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or...
8.
Weng C, Su H, Yang C, Shin K, Leou K, Tsai C
Nanotechnology . 2011 Jul; 17(22):5644-51. PMID: 21727337
Here we present a method to synthesize single-walled carbon nanotubes (SWNTs) selectively suspended on tips of silicon-based nanostructure (Si-ns) templates. The Si-ns templates vertically aligned to the substrates are fabricated...
9.
Yang C, Li Z, Rana T
RNA . 2011 Jun; 17(8):1451-60. PMID: 21693621
Although induced pluripotent stem cells (iPSCs) hold great promise for customized regenerative medicine, the molecular basis of reprogramming is largely unknown. Overcoming barriers that maintain cell identities is a critical...
10.
Li Z, Yang C, Nakashima K, Rana T
EMBO J . 2011 Feb; 30(5):823-34. PMID: 21285944
Somatic cells can be reprogrammed to an ES-like state to create induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and cMyc. Here, we...