Kuldeep K Roy
Overview
Explore the profile of Kuldeep K Roy including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
250
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Recent Articles
1.
Kashyap V, Sharma B, Pandey D, Singh A, Peasah-Darkwah G, Singh B, et al.
Cells
. 2025 Jan;
13(24.
PMID: 39768145
Metarrestin (ML246) is a first-in-class pyrrole-pyrimidine-derived small molecule that selectively targets the perinucleolar compartment (PNC). PNC is a distinct subnuclear structure predominantly found in solid tumor cells. The occurrence of...
2.
Pandey D, Roy K
Arch Biochem Biophys
. 2024 Dec;
764():110279.
PMID: 39710177
KRAS (Kirsten rat sarcoma viral oncogene homologue), the most common mutated protein in human cancers, is the leading cause of morbidity and mortality. Before Sotorasib (AMG-510) was approved for non-small...
3.
Pandey D, Chauhan S, Kashyap V, Roy K
Eur J Med Chem
. 2024 Aug;
277:116771.
PMID: 39167893
The Kirsten rat sarcoma viral (KRAS) oncogene is the most frequently mutated isoform of RAS, associated with 85 % of RAS-driven cancers. KRAS functions as a signaling hub, participating in...
4.
Bhardwaj S, Roy K
Curr Drug Targets
. 2023 Dec;
25(2):108-120.
PMID: 38151841
Antimicrobial resistance (AMR) to currently available antibiotics/drugs is a global threat. It is desirable to develop new drugs that work through a novel target(s) to avoid drug resistance. This review...
5.
Ray B, Roy K
J Biomol Struct Dyn
. 2023 Dec;
43(6):2968-2981.
PMID: 38111165
The cytochrome supercomplex, a key component in the electron transport chain pathway involved in bacterial energy production and homeostasis, is a clinically validated target for tuberculosis (TB), leading to Telacebec...
6.
Sarkar N, Khanal P, Rawat R, Dey Y, Roy K
J Biomol Struct Dyn
. 2023 Oct;
42(23):12720-12729.
PMID: 37878080
Tuberculosis is one of the most dreadful infectious diseases, afflicting global populations with anguish. With the emergence of multi-drug resistant strains of mycobacteria, the imperative for new anti-tuberculosis drugs has...
7.
Kumar D, Sarkar N, Roy K, Bisht D, Kumar D, Mandal B, et al.
Curr Drug Targets
. 2023 Jun;
24(8):627-647.
PMID: 37291783
The extensive development in the strains of resistant bacteria is a potential hazard to public health worldwide. This necessitates the development of newer agents with the antibacterial property having new...
8.
Nandi A, Das A, Dey Y, Roy K
Life (Basel)
. 2023 Mar;
13(3).
PMID: 36983855
The endocannabinoid system consists of several phytocannabinoids, cannabinoid receptors, and enzymes that aid in numerous steps necessary to manifest any pharmacological activity. It is well known that the endocannabinoid system...
9.
Roy K, Jyothi D, Paul U, Sukla S
J Biomol Struct Dyn
. 2023 Mar;
41(23):13993-14002.
PMID: 36970872
There is currently no drug available to treat mosquito-borne dengue. The C-terminal RNA-dependent RNA polymerase (RdRp) domain in the non-structural type 5 (NS5) protein of the dengue virus (DENV) is...
10.
Kundu M, Dutta A, Roy K, Mal S, Karmakar S, Mandal A, et al.
Chem Biol Drug Des
. 2022 Nov;
101(3):690-695.
PMID: 36322010
Malaria continues to be a significant public health problem threatened by the emergence and spread of resistance to artemisinin-based combination therapies and marked half a million deaths in 2016. A...