Krystal Herman
Overview
Explore the profile of Krystal Herman including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
7
Citations
217
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Tanis V, Venkatesan H, Cummings M, Albers M, Barbay J, Herman K, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(12):1463-1470.
PMID: 31010722
We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These molecules are potent binders but...
2.
Castro G, Liu X, Ngo K, De Leon-Tabaldo A, Zhao S, Luna-Roman R, et al.
PLoS One
. 2017 Aug;
12(8):e0181868.
PMID: 28763457
RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17...
3.
Blevitt J, Hack M, Herman K, Chang L, Keith J, Mirzadegan T, et al.
J Biol Chem
. 2016 Apr;
291(24):12724-12731.
PMID: 27129215
5-Lipoxygenase activating protein (FLAP) plays a critical role in the metabolism of arachidonic acid to leukotriene A4, the precursor to the potent pro-inflammatory mediators leukotriene B4 and leukotriene C4 Studies...
4.
Soroosh P, Wu J, Xue X, Song J, Sutton S, Sablad M, et al.
Proc Natl Acad Sci U S A
. 2014 Aug;
111(33):12163-8.
PMID: 25092323
The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17-producing CD4(+) Th17 T cells, which are essential in host defense and may play key pathogenic...
5.
Eccles W, Blevitt J, Booker J, Chrovian C, Crawford S, de Leon A, et al.
Bioorg Med Chem Lett
. 2012 Dec;
23(3):811-5.
PMID: 23260350
Leukotrienes (LT's) are known to play a physiological role in inflammatory immune response. Leukotriene A(4) hydrolase (LTA(4)H) is a cystolic enzyme that stereospecifically catalyzes the transformation of LTA(4) to LTB(4)....
6.
Tanis V, Bacani G, Blevitt J, Chrovian C, Crawford S, De Leon A, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7504-11.
PMID: 23127888
Previously, benzthiazole containing LTA(4)H inhibitors were discovered that were potent (1-3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering...
7.
Grasis J, Guimond D, Cam N, Herman K, Magotti P, Lambris J, et al.
Mol Cell Biol
. 2010 May;
30(14):3596-609.
PMID: 20457812
In vitro data have suggested that activation of the inducible T-cell kinase (ITK) requires an interaction with the adaptor protein SLP-76. One means for this interaction involves binding of the...