Wai-Ping Fung-Leung
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Explore the profile of Wai-Ping Fung-Leung including associated specialties, affiliations and a list of published articles.
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29
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1712
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Recent Articles
1.
Liu J, Chang H, Huang Z, Nakamura M, Sekhon S, Ahn R, et al.
J Allergy Clin Immunol
. 2020 Dec;
147(6):2370-2380.
PMID: 33309739
Background: Psoriasis is an inflammatory, IL-17-driven skin disease in which autoantigen-induced CD8 T cells have been identified as pathogenic drivers. Objective: Our study focused on comprehensively characterizing the phenotypic variation...
2.
Eckert 3rd W, Wiener J, Cai H, Ameriks M, Zhu J, Ngo K, et al.
Eur J Pharmacol
. 2020 May;
880:173171.
PMID: 32437743
Cathepsin S (CatS) is a cysteine protease found in lysosomes of hematopoietic and microglial cells and in secreted form in the extracellular space. While CatS has been shown to contribute...
3.
Cai Y, Yu J, Ren P, He J, Wu Z, Xiao K, et al.
Pharmacol Res Perspect
. 2020 Jan;
8(1):e00559.
PMID: 31956418
Phosphoinositide 3-kinases, delta (PI3Kδ) and gamma (PI3Kγ) are enriched in immune cells and regulate the development and function of innate and adaptive immunity. Dual PI3Kδγ inhibitors are considered high value...
4.
Bednar K, Nycholat C, Rao T, Paulson J, Fung-Leung W, Macauley M
ACS Chem Biol
. 2019 Mar;
14(4):644-654.
PMID: 30835424
Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects the synovial joints and can lead to bone erosion and cartilage damage. One hallmark of RA is anticitrullinated protein autoantibodies...
5.
Zhang R, Qi C, Hu Y, Shan Y, Hsieh Y, Xu F, et al.
J Autoimmun
. 2018 Sep;
96:113-122.
PMID: 30241692
The follicular helper T cell (T) are established regulators of germinal center (GC) B cells, whether T have pathogenic potential independent of B cells is unknown. Based on in vitro...
6.
Bednar K, Shanina E, Ballet R, Connors E, Duan S, Juan J, et al.
J Immunol
. 2017 Oct;
199(9):3116-3128.
PMID: 28972089
CD22, a sialic acid-binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on...
7.
Castro G, Liu X, Ngo K, De Leon-Tabaldo A, Zhao S, Luna-Roman R, et al.
PLoS One
. 2017 Aug;
12(8):e0181868.
PMID: 28763457
RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17...
8.
Blanco L, Plegue M, Fung-Leung W, Holoshitz J
J Immune Based Ther Vaccines Antimicrob
. 2017 Jul;
2(3):29-38.
PMID: 28748127
Susceptibility to rheumatoid arthritis (RA) is associated with alleles coding a 5-amino acid sequence motif called the shared epitope (SE). To explore the potential mechanisms that lead to RA susceptibility,...
9.
Fung-Leung W, Edwards W, Liu Y, Ngo K, Angsana J, Castro G, et al.
PLoS One
. 2017 Jan;
12(1):e0170102.
PMID: 28107393
Kv1.3 is a voltage-gated potassium channel expressed on T cells that plays an important role in T cell activation. Previous studies have shown that blocking Kv1.3 channels in human T...
10.
Xue X, Soroosh P, De Leon-Tabaldo A, Luna-Roman R, Sablad M, Rozenkrants N, et al.
Sci Rep
. 2016 Dec;
6:37977.
PMID: 27905482
The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy. Retinoid-related orphan nuclear receptor gamma t (RORγt) is required...