Kritarth Singh
Overview
Explore the profile of Kritarth Singh including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
528
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Recent Articles
1.
Whitehead M, Harvey J, Sladen P, Becchi G, Singh K, Sun Y, et al.
Acta Neuropathol Commun
. 2025 Feb;
13(1):28.
PMID: 39948685
Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, characterised by the selective loss of retinal ganglion cells (RGCs). Over 60% of DOA cases are caused by pathogenic...
2.
Chung C, Singh K, Sheshadri P, Valdebenito G, Chacko A, Costa Besada M, et al.
Autophagy
. 2024 Dec;
:1-16.
PMID: 39667405
Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) and is the most common pathogenic mtDNA...
3.
Singh K, Duchen M
Methods Mol Biol
. 2022 Jun;
2497:339-348.
PMID: 35771456
Blue Native polyacrylamide gel electrophoresis (BN-PAGE) is a well-established technique for the isolation and separation of mitochondrial membrane protein complexes in a native conformation with high resolution. In combination with...
4.
Roy M, Singh K, Shinde A, Singh J, Mane M, Bedekar S, et al.
Cell Signal
. 2021 Dec;
91:110210.
PMID: 34871740
Ubiquitin E3-ligases are recruited at different steps of TNF-α-induced NF-κB activation; however, their role in temporal regulation of the pathway remains elusive. The study systematically identified TRIMs as potential feedback...
5.
Chung C, Singh K, Kotiadis V, Valdebenito G, Ahn J, Topley E, et al.
Nat Commun
. 2021 Nov;
12(1):6409.
PMID: 34737295
Mutations of the mitochondrial genome (mtDNA) cause a range of profoundly debilitating clinical conditions for which treatment options are very limited. Most mtDNA diseases show heteroplasmy - tissues express both...
6.
Deneubourg C, Ramm M, Smith L, Baron O, Singh K, Byrne S, et al.
Autophagy
. 2021 Jun;
18(3):496-517.
PMID: 34130600
Primary dysfunction of autophagy due to Mendelian defects affecting core components of the autophagy machinery or closely related proteins have recently emerged as an important cause of genetic disease. This...
7.
Shinde A, Jung H, Lee H, Singh K, Roy M, Gohel D, et al.
Cancer Metab
. 2021 Apr;
9(1):19.
PMID: 33926547
Background: Tumor necrosis factor-α (TNF-α) is an immunostimulatory cytokine that is consistently high in the breast tumor microenvironment (TME); however, its differential role in mitochondrial functions and cell survival in...
8.
Vasiyani H, Shinde A, Roy M, Mane M, Singh K, Singh J, et al.
Apoptosis
. 2021 Apr;
26(5-6):293-306.
PMID: 33840002
Immune adaptor protein like STING/MITA regulate innate immune response and plays a critical role in inflammation in the tumor microenvironment and regulation of metastasis including breast cancer. Chromosomal instability in...
9.
Gohel D, Sripada L, Prajapati P, Currim F, Roy M, Singh K, et al.
Free Radic Biol Med
. 2021 Jan;
165:100-110.
PMID: 33497798
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disorder caused by an expansion of 55 to 200 CGG repeats located within 5'UTR of FMR1.These CGG repeats are transcribed into...
10.
Currim F, Singh J, Shinde A, Gohel D, Roy M, Singh K, et al.
Mol Neurobiol
. 2021 Jan;
58(4):1819-1833.
PMID: 33404982
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta region of the brain. The main pathological hallmark...