Kristijan Ramadan
Overview
Explore the profile of Kristijan Ramadan including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1905
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Recent Articles
1.
Song W, Zhao Y, Ruggiano A, Redfield C, Newman J, Zhu X, et al.
bioRxiv
. 2024 Dec;
PMID: 39651247
DNA-protein crosslinks (DPCs) are endogenous and chemotherapy-induced genotoxic DNA lesions and, if not repaired, lead to embryonic lethality, neurodegeneration, premature ageing, and cancer. DPCs are heavily polyubiquitinated, and the SPRTN...
2.
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Anticevic I, Otten C, et al.
Cell
. 2024 Sep;
187(20):5698-5718.e26.
PMID: 39265577
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of...
3.
Torrecilla I, Ruggiano A, Kiianitsa K, Aljarbou F, Lascaux P, Hoslett G, et al.
Nucleic Acids Res
. 2023 Dec;
52(2):525-547.
PMID: 38084926
DNA-protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication, transcription and DNA damage...
4.
Song W, Ramadan K
Mol Cell
. 2023 Dec;
83(23):4197-4199.
PMID: 38065058
In this issue of Molecular Cell, Rahmanto et al. and Zhao et al. demonstrate that RNA-protein crosslinks contribute to formaldehyde toxicity by blocking protein synthesis. Furthermore, they identify a ubiquitin-mediated...
5.
Hernandez-Carralero E, Cabrera E, Rodriguez-Torres G, Hernandez-Reyes Y, Singh A, Santa-Maria C, et al.
Nucleic Acids Res
. 2023 Mar;
51(11):5396-5413.
PMID: 36971114
The deubiquitinating enzyme Ataxin-3 (ATXN3) contains a polyglutamine (PolyQ) region, the expansion of which causes spinocerebellar ataxia type-3 (SCA3). ATXN3 has multiple functions, such as regulating transcription or controlling genomic...
6.
Kilgas S, Ramadan K
Cell Chem Biol
. 2023 Jan;
30(1):3-21.
PMID: 36640759
Protein homeostasis deficiencies underlie various cancers and neurodegenerative diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most of the protein degradation in mammalian cells and, therefore, represent attractive...
7.
Krastev D, Li S, Sun Y, Wicks A, Hoslett G, Weekes D, et al.
Nat Cell Biol
. 2022 Jan;
24(1):62-73.
PMID: 35013556
Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. How cells process trapped PARP1 remains unclear. Using wild-type and a...
8.
Kilgas S, Kiltie A, Ramadan K
STAR Protoc
. 2021 Dec;
2(4):100978.
PMID: 34888531
DNA end resection converts broken ends of double-stranded DNA (dsDNA) to 3'-single-stranded DNA (3'-ssDNA). The extent of resection regulates DNA double-strand break (DSB) repair pathway choice and thereby genomic stability....
9.
Ruggiano A, Vaz B, Kilgas S, Popovic M, Rodriguez-Berriguete G, Singh A, et al.
Cell Rep
. 2021 Dec;
37(10):110080.
PMID: 34879279
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer, neurodegeneration, and accelerated aging. DPC...
10.
Hume S, Grou C, Lascaux P, DAngiolella V, Legrand A, Ramadan K, et al.
Nat Commun
. 2021 Nov;
12(1):6959.
PMID: 34845229
Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and promotes oncogenesis, underlining the...