Igor Shevelev
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Explore the profile of Igor Shevelev including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
725
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Recent Articles
1.
Csefalvay E, Lapkouski M, Guzanova A, Csefalvay L, Baikova T, Shevelev I, et al.
PLoS One
. 2015 Jun;
10(6):e0128700.
PMID: 26039067
Type I restriction-modification enzymes are multifunctional heteromeric complexes with DNA cleavage and ATP-dependent DNA translocation activities located on motor subunit HsdR. Functional coupling of DNA cleavage and translocation is a...
2.
Villani G, Shevelev I, Orlando E, Pospiech H, Syvaoja J, Markkanen E, et al.
PLoS One
. 2014 Apr;
9(4):e93908.
PMID: 24710081
DNA polymerase ε (pol ε) is believed to be the leading strand replicase in eukaryotes whereas pols λ and β are thought to be mainly involved in re-synthesis steps of...
3.
Simandlova J, Zagelbaum J, Payne M, Chu W, Shevelev I, Hanada K, et al.
J Biol Chem
. 2013 Oct;
288(47):34168-34180.
PMID: 24108124
Efficient repair of DNA double strand breaks and interstrand cross-links requires the homologous recombination (HR) pathway, a potentially error-free process that utilizes a homologous sequence as a repair template. A...
4.
Snider J, Hanif A, Lee M, Jin K, Yu A, Graham C, et al.
Nat Chem Biol
. 2013 Jul;
9(9):565-72.
PMID: 23831759
ATP-binding cassette (ABC) transporters are a ubiquitous class of integral membrane proteins of immense clinical interest because of their strong association with human disease and pharmacology. To improve our understanding...
5.
Singh D, Popuri V, Kulikowicz T, Shevelev I, Ghosh A, Ramamoorthy M, et al.
Nucleic Acids Res
. 2012 May;
40(14):6632-48.
PMID: 22544709
Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4,...
6.
Villani G, Hubscher U, Gironis N, Parkkinen S, Pospiech H, Shevelev I, et al.
J Biol Chem
. 2011 Jul;
286(37):32094-104.
PMID: 21757740
DNA polymerase (pol) ε is thought to be the leading strand replicase in eukaryotes, whereas pols λ and β are believed to be mainly involved in re-synthesis steps of DNA...
7.
Kanagaraj R, Huehn D, MacKellar A, Menigatti M, Zheng L, Urban V, et al.
Nucleic Acids Res
. 2010 Aug;
38(22):8131-40.
PMID: 20705653
It is known that transcription can induce DNA recombination, thus compromising genomic stability. RECQ5 DNA helicase promotes genomic stability by regulating homologous recombination. Recent studies have shown that RECQ5 forms...
8.
Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, et al.
J Biol Chem
. 2010 Mar;
285(21):15739-45.
PMID: 20348101
Homologous recombination (HR) provides an efficient mechanism for error-free repair of DNA double-strand breaks (DSBs). However, HR can be also harmful as inappropriate or untimely HR events can give rise...
9.
Dietschy T, Shevelev I, Pena-Diaz J, Huhn D, Kuenzle S, Mak R, et al.
J Cell Sci
. 2009 Mar;
122(Pt 8):1258-67.
PMID: 19299466
RECQL4 belongs to the conserved RecQ family of DNA helicases, members of which play important roles in the maintenance of genome stability in all organisms that have been examined. Although...
10.
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori A, Gerrits B, et al.
Nucleic Acids Res
. 2009 Mar;
37(8):2645-57.
PMID: 19270065
RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments. Here, we show that RECQ5 is constitutively associated with the MRE11-RAD50-NBS1 (MRN) complex, a primary sensor of...