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Kristian Kolby Kristensen

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Articles 9
Citations 299
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Recent Articles
1.
Biswas A, Arshid S, Kristensen K, Jorgensen T, Ploug M
J Lipid Res . 2025 Jan; 66(2):100745. PMID: 39814316
Movement of lipoprotein lipase (LPL) from myocytes or adipocytes to the capillary lumen is essential for intravascular lipolysis and plasma triglyceride homeostasis-low LPL activity in the capillary lumen causes hypertriglyceridemia....
2.
Lund Winther A, Kristensen K, Kumari A, Ploug M
J Lipid Res . 2021 Nov; 62:100149. PMID: 34780727
LPL is essential for intravascular lipid metabolism and is of high medical relevance. Since LPL is notoriously unstable, there is an unmet need for a robust expression system producing high...
3.
Kristensen K, Leth-Espensen K, Kumari A, Gronnemose A, Lund-Winther A, Young S, et al.
Front Cell Dev Biol . 2021 Aug; 9:702508. PMID: 34336854
Intravascular processing of triglyceride-rich lipoproteins (TRLs) is crucial for delivery of dietary lipids fueling energy metabolism in heart and skeletal muscle and for storage in white adipose tissue. During the...
4.
Sjogaard-Frich L, Prestel A, Pedersen E, Severin M, Kristensen K, Olsen J, et al.
Elife . 2021 Mar; 10. PMID: 33655882
Calmodulin (CaM) engages in Ca-dependent interactions with numerous proteins, including a still incompletely understood physical and functional interaction with the human Na/H-exchanger NHE1. Using nuclear magnetic resonance (NMR) spectroscopy, isothermal...
5.
Kristensen K, Leth-Espensen K, Young S, Ploug M
J Lipid Res . 2020 Apr; 61(9):1253. PMID: 32327484
No abstract available.
6.
Leth J, Leth-Espensen K, Kristensen K, Kumari A, Lund Winther A, Young S, et al.
Int J Mol Sci . 2019 Jun; 20(11). PMID: 31195646
Proteins containing Ly6/uPAR (LU) domains exhibit very diverse biological functions and have broad taxonomic distributions in eukaryotes. In general, they adopt a characteristic three-fingered folding topology with three long loops...
7.
Kovrov O, Kristensen K, Larsson E, Ploug M, Olivecrona G
J Lipid Res . 2019 Jan; 60(4):783-793. PMID: 30686789
Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3,...
8.
Birrane G, Beigneux A, Dwyer B, Strack-Logue B, Kristensen K, Francone O, et al.
Proc Natl Acad Sci U S A . 2018 Dec; 116(5):1723-1732. PMID: 30559189
Lipoprotein lipase (LPL) is responsible for the intravascular processing of triglyceride-rich lipoproteins. The LPL within capillaries is bound to GPIHBP1, an endothelial cell protein with a three-fingered LU domain and...
9.
Mysling S, Kristensen K, Larsson M, Kovrov O, Bensadouen A, Jorgensen T, et al.
Elife . 2016 Dec; 5. PMID: 27929370
Lipoprotein lipase (LPL) undergoes spontaneous inactivation global unfolding and this unfolding is prevented by GPIHBP1 (Mysling et al., 2016). We now show: (1) that ANGPTL4 inactivates LPL by catalyzing the...
10.
Mysling S, Kristensen K, Larsson M, Beigneux A, Gardsvoll H, Fong L, et al.
Elife . 2016 Jan; 5:e12095. PMID: 26725083
GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen. The LPL•GPIHBP1 complex is...