Krishnapriya Chinnaswamy
Overview
Explore the profile of Krishnapriya Chinnaswamy including associated specialties, affiliations and a list of published articles.
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35
Citations
921
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Recent Articles
1.
Yang L, Tu W, Leng L, Huang L, Jiang W, Wang M, et al.
J Med Chem
. 2025 Jan;
68(2):1155-1178.
PMID: 39745073
SMARCA2 is an attractive synthetic lethal target in human cancers with mutated, inactivated SMARCA4. We report herein the discovery of highly potent and selective SMARCA2 PROTAC degraders, as exemplified by...
2.
Leng L, Tu W, Yang L, Huang L, Wang M, Meagher J, et al.
J Med Chem
. 2025 Jan;
68(2):1113-1133.
PMID: 39745064
In the SWI/SNF chromatin-remodeling complex, the mutually exclusive catalytic ATPase subunits SMARCA2 and SMARCA4 proteins have a synthetic-lethal relationship. Selectively targeting SMARCA2 for degradation is a promising and new therapeutic...
3.
Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya R, et al.
J Med Chem
. 2024 Nov;
67(22):20495-20513.
PMID: 39509603
STAT3 is an attractive therapeutic target for cancer and other human diseases. We have previously reported the discovery of potent, selective, and efficacious PROTAC STAT3 degraders SD-36 and SD-91. In...
4.
Kaneshige A, Yang Y, Bai L, Wang M, Xu R, Mallik L, et al.
J Med Chem
. 2024 Sep;
68(5):5125-5151.
PMID: 39311434
STAT6 is an attractive therapeutic target for human cancers and other human diseases. Starting from a STAT6 ligand with = 3.5 μM binding affinity, we obtained AK-068 with = 6...
5.
Yuan X, Kazemi Sabzvar M, Patil A, Chinnaswamy K, Howie K, Andhavaram R, et al.
Res Sq
. 2024 Jun;
PMID: 38883705
Mutations in RNA splicing factor genes including , , and have been reported to contribute to development of myeloid neoplasms including myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML)....
6.
Yuan X, Jiang H, Fu D, Rech J, Robida A, Rajanayake K, et al.
ACS Pharmacol Transl Sci
. 2023 Sep;
6(9):1275-1287.
PMID: 37705593
Hematopoietic cell transplantation (HCT) is a proven and potentially curable therapy for hematological malignancies and inherited hematological disease. The main risk of HCT is the development of graft versus host...
7.
Yuan X, Howie K, Kazemi Sabzvar M, Chinnaswamy K, Stuckey J, Yang C
ACS Med Chem Lett
. 2023 May;
14(5):681.
PMID: 37197465
[This corrects the article DOI: 10.1021/acsmedchemlett.2c00537.].
8.
Yuan X, Howie K, Kazemi Sabzvar M, Chinnaswamy K, Stuckey J, Yang C
ACS Med Chem Lett
. 2023 Apr;
14(4):450-457.
PMID: 37077390
RNA splicing is a biological process to generate mature mRNA (mRNA) by removing introns and annexing exons in the nascent RNA transcript and is executed by a multiprotein complex called...
9.
Yuan X, Jiang H, Fu D, Robida A, Rajanayake K, Yuan H, et al.
Bioorg Med Chem
. 2022 Aug;
71:116942.
PMID: 35930851
An elevated plasma level of soluble ST2 (sST2) is a risk biomarker for graft-versus-host disease (GVHD) and death in patients receiving hematopoietic cell transplantation (HCT). sST2 functions as a trap...
10.
Yuan X, Chinnaswamy K, Stuckey J, Yang C
J Phys Chem B
. 2022 Mar;
126(12):2394-2406.
PMID: 35294837
Cytokine signaling initiated by the binding of the cytokine receptors to cytokines plays important roles in immune regulation and diseases. Structurally, cytokine receptors interact with cytokines via an extensive, rugged...