Shaomeng Wang
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Explore the profile of Shaomeng Wang including associated specialties, affiliations and a list of published articles.
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451
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Recent Articles
1.
Nwosu Z, Giza H, Giza H, Nassif M, Charlestin V, Menjivar R, et al.
JCI Insight
. 2025 Jan;
10(4).
PMID: 39774001
Pancreatic ductal adenocarcinoma (PDAC) is a drug-resistant and lethal cancer. Identification of the genes that consistently show altered expression across patient cohorts can expose effective therapeutic targets and strategies. To...
2.
Yang L, Tu W, Leng L, Huang L, Jiang W, Wang M, et al.
J Med Chem
. 2025 Jan;
68(2):1155-1178.
PMID: 39745073
SMARCA2 is an attractive synthetic lethal target in human cancers with mutated, inactivated SMARCA4. We report herein the discovery of highly potent and selective SMARCA2 PROTAC degraders, as exemplified by...
3.
Leng L, Tu W, Yang L, Huang L, Wang M, Meagher J, et al.
J Med Chem
. 2025 Jan;
68(2):1113-1133.
PMID: 39745064
In the SWI/SNF chromatin-remodeling complex, the mutually exclusive catalytic ATPase subunits SMARCA2 and SMARCA4 proteins have a synthetic-lethal relationship. Selectively targeting SMARCA2 for degradation is a promising and new therapeutic...
4.
Wang S, Li X, Zhu M, Deng H, Wang J, Zhang J
PLoS Pathog
. 2024 Dec;
20(12):e1012801.
PMID: 39724263
Human pathogen Streptococcus pneumoniae forms multiple epigenetically and phenotypically distinct intra-populations by invertase PsrA-driven inversions of DNA methyltransferase hsdS genes in the colony opacity-determinant (cod) locus. As manifested by phase...
5.
Song Z, Sun Y, Liu P, Ruan H, He Y, Yin J, et al.
Research (Wash D C)
. 2024 Dec;
7:0535.
PMID: 39664293
Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy...
6.
Rej R, Hu B, Chen Z, Acharyya R, Wu D, Metwally H, et al.
J Med Chem
. 2024 Nov;
67(23):20933-20965.
PMID: 39585895
Inhibition of estrogen receptor alpha (ERα) signaling is an established therapeutic approach for the treatment of ER-positive (ER+) breast cancers, but new therapeutic strategies are urgently needed to overcome clinical...
7.
Wang Q, Su T, Cheng F, Zhou S, Liu X, Wang M, et al.
bioRxiv
. 2024 Nov;
PMID: 39574605
Protein/peptide subunit vaccines are promising to promote the tumor therapeutic efficacy of immune checkpoint blockade (ICB). However, current protein/peptide vaccines elicit limited antitumor T cell responses, leading to suboptimal therapeutic...
8.
Li Z, Harikrishnan L, Xu G, Samanta D, Clemente J, Leng L, et al.
J Med Chem
. 2024 Nov;
68(2):1134-1154.
PMID: 39570797
We describe the identification of selective SMARCA2, VHL-based heterobifunctional degraders. Structurally novel indolo[1,2-]quinazolin-5(7)-one SMARCA bromodomain binders were optimized and then converted to SMARCA2 degraders by linking them to well-defined VHL...
9.
Lin H, Tison K, Du Y, Kirchhoff P, Kim C, Wang W, et al.
Cancer Cell
. 2024 Nov;
42(12):2032-2044.e6.
PMID: 39515327
Immune checkpoint blockade (ICB) triggers tumor ferroptosis. However, most patients are unresponsive to ICB. Tumors might evade ferroptosis in the tumor microenvironment (TME). Here, we discover SLC13A3 is an itaconate...
10.
Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya R, et al.
J Med Chem
. 2024 Nov;
67(22):20495-20513.
PMID: 39509603
STAT3 is an attractive therapeutic target for cancer and other human diseases. We have previously reported the discovery of potent, selective, and efficacious PROTAC STAT3 degraders SD-36 and SD-91. In...