Konstantinos Thalassinos
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Explore the profile of Konstantinos Thalassinos including associated specialties, affiliations and a list of published articles.
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79
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1409
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Recent Articles
1.
Bradford H, Lalaurie C, Gor J, Gao X, Pericleous C, Perkins S, et al.
J Thromb Haemost
. 2025 Feb;
PMID: 40010569
Methods: β2GPI was purified using an adapted acid-free process from healthy control plasma and cleaved with plasmin. Cleavage was confirmed by SDS-PAGE. Structural characterisation was undertaken using dynamic light scattering...
2.
Newton L, Gathmann C, Ridewood S, Smith R, Wijaya A, Hornsby T, et al.
Nat Commun
. 2025 Feb;
16(1):1484.
PMID: 39929804
Targeting host proteins that are crucial for viral replication offers a promising antiviral strategy. We have designed and characterised antiviral PROteolysis TArgeting Chimeras (PROTACs) targeting the human protein cyclophilin A...
3.
Saridakis I, Adoni K, Leischner T, Brutiu B, Shaaban S, Ferrari G, et al.
Anal Chem
. 2025 Jan;
97(2):1273-1280.
PMID: 39785238
Chemical cross-linking/mass spectrometry (XL-MS) has emerged as a complementary tool for mapping interaction sites within protein networks as well as gaining moderate-resolution native structural insight with minimal interference. XL-MS technology...
4.
Iseppon F, Kanellopoulos A, Tian N, Zhou J, Caan G, Chiozzi R, et al.
Neurobiol Pain
. 2024 Nov;
16:100168.
PMID: 39559752
Genetic deletion and pharmacological inhibition are distinct approaches to unravelling pain mechanisms, identifying targets and developing new analgesics. Both approaches have been applied to the voltage-gated sodium channels Na1.7 and...
5.
Erinjeri A, Wang X, Williams R, Chiozzi R, Thalassinos K, Labbadia J
Nat Commun
. 2024 Nov;
15(1):9797.
PMID: 39532882
Increased activity of the heat shock factor, HSF-1, suppresses proteotoxicity and enhances longevity. However, the precise mechanisms by which HSF-1 promotes lifespan are unclear. Using an RNAi screen, we identify...
6.
Britt H, Ben-Younis A, Page N, Thalassinos K
J Am Soc Mass Spectrom
. 2024 Oct;
35(12):3203-3213.
PMID: 39453623
Native top-down mass spectrometry is a powerful approach for characterizing proteoforms and has recently been applied to provide similarly powerful insights into protein conformation. Current approaches, however, are limited such...
7.
Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells
Anver S, Sumit A, Sun X, Hatimy A, Thalassinos K, Marguerat S, et al.
EMBO Rep
. 2024 Oct;
25(11):4921-4949.
PMID: 39358553
Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent fission yeast cells. Deletion of aal1 shortens the chronological...
8.
Dai Z, Ben-Younis A, Vlachaki A, Raleigh D, Thalassinos K
Biophys Chem
. 2024 Jun;
312:107285.
PMID: 38941872
Human islet amyloid polypeptide (hIAPP) forms amyloid deposits that contribute to β-cell death in pancreatic islets and are considered a hallmark of Type II diabetes Mellitus (T2DM). Evidence suggests that...
9.
Manalastas-Cantos K, Adoni K, Pfeifer M, Martens B, Grunewald K, Thalassinos K, et al.
Mol Cell Proteomics
. 2024 Jan;
23(3):100724.
PMID: 38266916
We propose a pipeline that combines AlphaFold2 (AF2) and crosslinking mass spectrometry (XL-MS) to model the structure of proteins with multiple conformations. The pipeline consists of two main steps: ensemble...
10.
Vickers S, Irving J, Lomas D, Thalassinos K
Methods Mol Biol
. 2023 Dec;
2750:41-55.
PMID: 38108966
In this chapter, we describe a method for analyzing both recombinant and plasma-derived alpha 1 antitrypsin and its oligomers by means of native ion mobility mass spectrometry. Our experimental workflow...