Konstantinos Thalassinos
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Explore the profile of Konstantinos Thalassinos including associated specialties, affiliations and a list of published articles.
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79
Citations
1409
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Recent Articles
11.
Gardner S, Darrow M, Lukoyanova N, Thalassinos K, Saibil H
Proc Natl Acad Sci U S A
. 2023 Dec;
120(50):e2308933120.
PMID: 38064510
The bacterial chaperonin GroEL-GroES promotes protein folding through ATP-regulated cycles of substrate protein binding, encapsulation, and release. Here, we have used cryoEM to determine structures of GroEL, GroEL-ADP·BeF, and GroEL-ADP·AlF-GroES...
12.
Ofer S, Blombach F, Erkelens A, Barker D, Soloviev Z, Schwab S, et al.
Commun Biol
. 2023 Sep;
6(1):968.
PMID: 37740023
In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric and assemble on DNA into 'hypernucleosome' particles of...
13.
Levray Y, Bana B, Tarr S, McLaughlin E, Rossi-Smith P, Waltho A, et al.
PLoS Pathog
. 2023 Mar;
19(3):e1011281.
PMID: 37000891
During the blood stage of a malaria infection, malaria parasites export both soluble and membrane proteins into the erythrocytes in which they reside. Exported proteins are trafficked via the parasite...
14.
Morfopoulou S, Buddle S, Torres Montaguth O, Atkinson L, Guerra-Assuncao J, Moradi Marjaneh M, et al.
Nature
. 2023 Mar;
617(7961):564-573.
PMID: 36996872
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK. Here we report an investigation...
15.
Eldrid C, Cragnolini T, Ben-Younis A, Zou J, Raleigh D, Thalassinos K
Anal Chem
. 2022 Nov;
94(46):16113-16121.
PMID: 36350278
Native mass spectrometry coupled to ion mobility (IM-MS) combined with collisional activation (CA) of ions in the gas phase () is an important method for the study of protein unfolding....
16.
Romano L, Aw W, Hixson K, Novoselova T, Havener T, Howell S, et al.
Cell Rep
. 2022 Nov;
41(5):111580.
PMID: 36323248
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset cerebellar ataxia caused by mutations in SACS, which encodes the protein sacsin. Cellular ARSACS phenotypes include mitochondrial dysfunction, intermediate filament...
17.
Flomm F, Soh T, Schneider C, Wedemann L, Britt H, Thalassinos K, et al.
PLoS Pathog
. 2022 Aug;
18(8):e1010575.
PMID: 35925870
Human Cytomegalovirus (HCMV) can infect a variety of cell types by using virions of varying glycoprotein compositions. It is still unclear how this diversity is generated, but spatio-temporally separated envelopment...
18.
Bagneris C, Senthil Kumar S, Baratchian M, Britt H, Assafa T, Thalassinos K, et al.
J Biol Chem
. 2022 May;
298(6):102012.
PMID: 35525271
Constitutive activation of the canonical NF-κB signaling pathway is a major factor in Kaposi's sarcoma-associated herpes virus pathogenesis where it is essential for the survival of primary effusion lymphoma. Central...
19.
Britt H, Cragnolini T, Khatun S, Hatimy A, James J, Page N, et al.
Rapid Commun Mass Spectrom
. 2022 Mar;
36(13):e9308.
PMID: 35353398
Rationale: Analyte quantitation by mass spectrometry underpins a diverse range of scientific endeavors. The fast-growing field of mass spectrometer development has resulted in several targeted and untargeted acquisition modes suitable...
20.
Soloviev Z, Bullock J, James J, Sauerwein A, Nettleship J, Owens R, et al.
Biochim Biophys Acta Proteins Proteom
. 2022 Jan;
1870(3):140759.
PMID: 35051665
Human Histone Deacetylase 2 (HDAC2) belongs to a conserved enzyme superfamily that regulates deacetylation inside cells. HDAC2 is a drug target as it is known to be upregulated in cancers...