Konstantin E Komolov
Overview
Explore the profile of Konstantin E Komolov including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
17
Citations
336
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Phadte A, Bhatia M, Ebert H, Abdullah H, Abed Elrazaq E, Komolov K, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2302103120.
PMID: 37549289
Human genome-wide association studies have identified and several DNA mismatch repair (MMR) genes as modifiers of Huntington's disease age of onset. In animal models, FAN1 prevents somatic expansion of CAG...
2.
Ippolito M, De Pascali F, Hopfinger N, Komolov K, Laurinavichyute D, Reddy P, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(31):e2302668120.
PMID: 37490535
Catecholamine-stimulated β-adrenergic receptor (βAR) signaling via the canonical G-adenylyl cyclase-cAMP-PKA pathway regulates numerous physiological functions, including the therapeutic effects of exogenous β-agonists in the treatment of airway disease. βAR signaling...
3.
De Pascali F, Ippolito M, Wolfe E, Komolov K, Hopfinger N, Lemenze D, et al.
Br J Pharmacol
. 2022 Jun;
179(19):4692-4708.
PMID: 35732075
Background And Purpose: β-Adrenoceptor agonists relieve airflow obstruction by activating β -adrenoceptors, which are G protein-coupled receptors (GPCRs) expressed on human airway smooth muscle (HASM) cells. The currently available β-adrenoceptor...
4.
Komolov K, Sulon S, Bhardwaj A, van Keulen S, Duc N, Laurinavichyute D, et al.
Mol Cell
. 2020 Dec;
81(2):323-339.e11.
PMID: 33321095
The phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) facilitates arrestin binding and receptor desensitization. Although this process can be regulated by Ca-binding proteins such as calmodulin (CaM)...
5.
Komolov K, Benovic J
Cell Signal
. 2017 Jul;
41:17-24.
PMID: 28711719
This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one...
6.
Komolov K, Du Y, Duc N, Betz R, Rodrigues J, Leib R, et al.
Cell
. 2017 Apr;
169(3):407-421.e16.
PMID: 28431242
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural understanding of GPCR/G-protein and GPCR/arrestin...
7.
Komolov K, Bhardwaj A, Benovic J
J Biol Chem
. 2015 Jun;
290(34):20629-20647.
PMID: 26032409
G protein-coupled receptor kinases (GRKs) are members of the protein kinase A, G, and C families (AGC) and play a central role in mediating G protein-coupled receptor phosphorylation and desensitization....
8.
So C, Michal A, Komolov K, Luo J, Benovic J
Mol Biol Cell
. 2013 Aug;
24(18):2795-806.
PMID: 23904266
G protein-coupled receptor kinases (GRKs) play a central role in regulating receptor signaling, but recent studies suggest a broader role in modulating normal cellular functions. For example, GRK5 has been...
9.
Grigoriev I, Senin I, Tikhomirova N, Komolov K, Permyakov S, Zernii E, et al.
Front Mol Neurosci
. 2012 Mar;
5:28.
PMID: 22408603
Phosphorylation of photoactivated rhodopsin by rhodopsin kinase (RK or GRK1), a first step of the phototransduction cascade turnoff, is under the control of Ca(2+)/recoverin. Here, we demonstrate that calmodulin, a...
10.
Involvement of the recoverin C-terminal segment in recognition of the target enzyme rhodopsin kinase
Zernii E, Komolov K, Permyakov S, Kolpakova T, DellOrco D, Poetzsch A, et al.
Biochem J
. 2011 Feb;
435(2):441-50.
PMID: 21299498
NCS (neuronal Ca2+ sensor) proteins belong to a family of calmodulin-related EF-hand Ca2+-binding proteins which, in spite of a high degree of structural similarity, are able to selectively recognize and...