Kiran Sapkota
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Explore the profile of Kiran Sapkota including associated specialties, affiliations and a list of published articles.
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18
Citations
239
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Recent Articles
1.
Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, et al.
Elife
. 2024 Mar;
12.
PMID: 38529532
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in...
2.
Singh M, Sapkota K, Sakimura K, Kano M, Cowell R, Overstreet-Wadiche L, et al.
Neuroscience
. 2023 Jan;
513:38-53.
PMID: 36682446
N-methyl-D-aspartate receptor (NMDAR) hypofunction during brain development is likely to contribute to the manifestation of schizophrenia (SCZ) in young adulthood. The cellular targets of NMDAR hypofunction appear to be at...
3.
Nakao K, Singh M, Sapkota K, Fitzgerald A, Hablitz J, Nakazawa K
Transl Psychiatry
. 2022 Apr;
12(1):168.
PMID: 35459266
Blockade of N-methyl-D-aspartate receptors (NMDAR) is known to augment cortical serotonin 2A receptors (5-HT2ARs), which is implicated in psychosis. However, the pathways from NMDAR hypofunction to 5-HT2AR up-regulation are unclear....
4.
Sapkota K, Burnell E, Irvine M, Fang G, Gawande D, Dravid S, et al.
Neuropharmacology
. 2021 Oct;
201:108818.
PMID: 34610288
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a subtype of ionotropic glutamate receptor with important roles in CNS function. Since excessive NMDAR activity can lead to neuronal cell death and epilepsy, there...
5.
Nakao K, Singh M, Sapkota K, Hagler B, Hunter R, Raman C, et al.
Neuropsychopharmacology
. 2020 Aug;
45(13):2207-2218.
PMID: 32859995
Cortical gamma oscillations are believed to be involved in mental processes which are disturbed in schizophrenia. For example, the magnitudes of sensory-evoked oscillations, as measured by auditory steady-state responses (ASSRs)...
6.
Zhou Y, Chen J, Sapkota K, Long J, Liao Y, Jiang J, et al.
Biomed Pharmacother
. 2020 Apr;
127:110139.
PMID: 32302948
HIV-associated neurocognitive disorders (HAND) are characterized by synaptic damage and neuronal loss in the brain, ultimately leading to progressive decline of cognitive abilities and memory. Chemokine CC motif ligand 2...
7.
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Wang J, Irvine M, Burnell E, Sapkota K, Thatcher R, Li M, et al.
Nat Commun
. 2020 Jan;
11(1):423.
PMID: 31969570
N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for...
8.
Nakazawa K, Sapkota K
Pharmacol Ther
. 2019 Oct;
205:107426.
PMID: 31629007
N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in autism, Alzheimer's disease and cognitive dementia, it is crucial...
9.
Irvine M, Fang G, Sapkota K, Burnell E, Volianskis A, Costa B, et al.
Eur J Med Chem
. 2019 Jan;
164:471-498.
PMID: 30622023
The N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel activated by L-glutamate and glycine, plays a major role in the synaptic plasticity underlying learning and memory. NMDARs are involved in neurodegenerative...
10.
Sapkota K, Dore K, Tang K, Irvine M, Fang G, Burnell E, et al.
Biochem Pharmacol
. 2018 Dec;
159:140-153.
PMID: 30503374
N-methyl-d-aspartate receptors (NMDARs) have multiple prominent roles in CNS function but their excessive or insufficient activity contributes to neuropathological/psychiatric disorders. Consequently, a variety of positive and negative allosteric modulators (PAMs...