Daniel T Monaghan
Overview
Explore the profile of Daniel T Monaghan including associated specialties, affiliations and a list of published articles.
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36
Citations
942
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Recent Articles
1.
Collingridge G, Monaghan D
Neuropharmacology
. 2022 Mar;
210:109042.
PMID: 35307365
40 years ago, Jeff Watkins and Richard (Dick) Evans (Watkins and Evans, 1981) published their review on excitatory amino acids. The review, combined with the tools that they and their...
2.
Sapkota K, Burnell E, Irvine M, Fang G, Gawande D, Dravid S, et al.
Neuropharmacology
. 2021 Oct;
201:108818.
PMID: 34610288
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a subtype of ionotropic glutamate receptor with important roles in CNS function. Since excessive NMDAR activity can lead to neuronal cell death and epilepsy, there...
3.
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Wang J, Irvine M, Burnell E, Sapkota K, Thatcher R, Li M, et al.
Nat Commun
. 2020 Jan;
11(1):423.
PMID: 31969570
N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for...
4.
Mao Z, He S, Mesnard C, Synowicki P, Zhang Y, Chung L, et al.
Brain Res
. 2019 Dec;
1727:146571.
PMID: 31786200
NMDA receptor (NMDAR) antagonists such as ketamine, can reproduce many of the symptoms of schizophrenia. A reliable indicator of NMDAR channel blocker action in vivo is the augmentation of neuronal...
5.
Irvine M, Fang G, Sapkota K, Burnell E, Volianskis A, Costa B, et al.
Eur J Med Chem
. 2019 Jan;
164:471-498.
PMID: 30622023
The N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel activated by L-glutamate and glycine, plays a major role in the synaptic plasticity underlying learning and memory. NMDARs are involved in neurodegenerative...
6.
Sapkota K, Dore K, Tang K, Irvine M, Fang G, Burnell E, et al.
Biochem Pharmacol
. 2018 Dec;
159:140-153.
PMID: 30503374
N-methyl-d-aspartate receptors (NMDARs) have multiple prominent roles in CNS function but their excessive or insufficient activity contributes to neuropathological/psychiatric disorders. Consequently, a variety of positive and negative allosteric modulators (PAMs...
7.
Alsaad H, DeKorver N, Mao Z, Dravid S, Arikkath J, Monaghan D
Neurochem Res
. 2018 Apr;
44(1):61-77.
PMID: 29651654
N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the brain with high concentrations in the telencephalon where they modulate synaptic plasticity, working memory, and other functions. While the actions of the...
8.
Burnell E, Irvine M, Fang G, Sapkota K, Jane D, Monaghan D
J Med Chem
. 2018 Feb;
62(1):3-23.
PMID: 29446949
Excitatory activity in the CNS is predominately mediated by l-glutamate through several families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate receptor (NMDAR) family has many critical roles in CNS...
9.
Chopra D, Sapkota K, Irvine M, Fang G, Jane D, Monaghan D, et al.
Sci Rep
. 2017 Aug;
7(1):6933.
PMID: 28761055
NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this...
10.
Sapkota K, Irvine M, Fang G, Burnell E, Bannister N, Volianskis A, et al.
Neuropharmacology
. 2017 Jul;
125:64-79.
PMID: 28709671
The theory that N-methyl-d-aspartate receptor (NMDAR) hypofunction is responsible for the symptoms of schizophrenia is well supported by many pharmacological and genetic studies. Accordingly, positive allosteric modulators (PAMs) that augment...