King C Chan
Overview
Explore the profile of King C Chan including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
877
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0
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Recent Articles
1.
Wei C, Huang L, Kreh B, Liu X, Tyutyunyk-Massey L, Kawakami M, et al.
Sci Rep
. 2023 Sep;
13(1):14907.
PMID: 37689790
All-trans-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed cancer growth in syngeneic immunocompetent, but not immunodeficient mice....
2.
Lu X, Sabbasani V, Osei-Amponsa V, Evans C, King J, Tarasov S, et al.
Nat Commun
. 2021 Dec;
12(1):7318.
PMID: 34916494
Proteasome substrate receptor hRpn13 is a promising anti-cancer target. By integrated in silico and biophysical screening, we identified a chemical scaffold that binds hRpn13 with non-covalent interactions that mimic the...
3.
Kaczmarczyk J, Roberts R, Luke B, Chan K, Van Wagoner C, Felder R, et al.
Oncotarget
. 2021 Oct;
12(20):2022-2038.
PMID: 34611477
Lung cancer is the leading cause of cancer-related deaths in the USA and worldwide. Yet, about 95% of new drug candidates validated in preclinical phase eventually fail in clinical trials....
4.
Ilinskaya A, Shah A, Enciso A, Chan K, Kaczmarczyk J, Blonder J, et al.
Nanomedicine
. 2019 Feb;
17:266-275.
PMID: 30794962
The complement system plays an essential role in both innate and adaptive immunity. The traditional understanding of this system comes from studies investigating complement proteins produced by the liver and...
5.
Prieto D, Chan K, Johann Jr D, Ye X, Whitely G, Blonder J
Methods Mol Biol
. 2017 Aug;
1647:71-90.
PMID: 28808996
The discovery of novel drug targets and biomarkers via mass spectrometry (MS)-based proteomic analysis of clinical specimens has proven to be challenging. The wide dynamic range of protein concentration in...
6.
Kulkarni R, Worth A, Zengeya T, Shrimp J, Garlick J, Roberts A, et al.
Cell Chem Biol
. 2017 Feb;
24(2):231-242.
PMID: 28163016
Non-enzymatic protein modification driven by thioester reactivity is thought to play a major role in the establishment of cellular lysine acylation. However, the specific protein targets of this process are...
7.
Ye X, Chan K, Waters A, Bess M, Harned A, Wei B, et al.
Oncotarget
. 2016 Nov;
7(52):86948-86971.
PMID: 27894102
Oncogenic Ras mutants play a major role in the etiology of most aggressive and deadly carcinomas in humans. In spite of continuous efforts, effective pharmacological treatments targeting oncogenic Ras isoforms...
8.
Prieto D, Johann Jr D, Wei B, Ye X, Chan K, Nissley D, et al.
Biomark Med
. 2014 Feb;
8(2):269-86.
PMID: 24521024
The discovery of clinically relevant cancer biomarkers using mass spectrometry (MS)-based proteomics has proven difficult, primarily because of the enormous dynamic range of blood-derived protein concentrations and the fact that...
9.
Waybright T, Chan K, Veenstra T, Xiao Z
Methods Mol Biol
. 2013 Aug;
1061:279-89.
PMID: 23963944
The discovery of viable biomarkers or indicators of disease states is complicated by the inherent complexity of the chosen biological specimen. Every sample, whether it is serum, plasma, urine, tissue,...
10.
Chan K, Issaq H
Methods Mol Biol
. 2013 Apr;
1002:311-5.
PMID: 23625412
Chromatography in all its formats plays an important role in proteomics research. The search for protein biomarkers for different diseases has been an active area of research. The dynamic concentration...