David A Lucas
Overview
Explore the profile of David A Lucas including associated specialties, affiliations and a list of published articles.
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28
Citations
775
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Recent Articles
1.
Bennuru S, Meng Z, Ribeiro J, Tolouei Semnani R, Ghedin E, Chan K, et al.
Proc Natl Acad Sci U S A
. 2011 May;
108(23):9649-54.
PMID: 21606368
Global proteomic analyses of pathogens have thus far been limited to unicellular organisms (e.g., protozoa and bacteria). Proteomic analyses of most eukaryotic pathogens (e.g., helminths) have been restricted to specific...
2.
Sa-Nunes A, Bafica A, Lucas D, Conrads T, Veenstra T, Andersen J, et al.
J Immunol
. 2007 Jul;
179(3):1497-505.
PMID: 17641015
Tick saliva is thought to contain a number of molecules that prevent host immune and inflammatory responses. In this study, the effects of Ixodes scapularis saliva on cytokine production by...
3.
Andersen J, Hinnebusch B, Lucas D, Conrads T, Veenstra T, Pham V, et al.
BMC Genomics
. 2007 Apr;
8:102.
PMID: 17437641
Background: The salivary glands of hematophagous animals contain a complex cocktail that interferes with the host hemostasis and inflammation pathways, thus increasing feeding success. Fleas represent a relatively recent group...
4.
Yu L, Chan K, Tahara H, Lucas D, Chatterjee K, Issaq H, et al.
Biochem Biophys Res Commun
. 2007 Mar;
356(4):942-7.
PMID: 17395154
Telomeres play important functional roles in cell proliferation, cell cycle regulation, and genetic stability, in which telomere length is critical. In this study, quantitative proteome comparisons for the human breast...
5.
Xiao Z, Camalier C, Nagashima K, Chan K, Lucas D, de la Cruz M, et al.
J Cell Physiol
. 2006 Nov;
210(2):325-35.
PMID: 17096383
Many key processes central to bone formation and homeostasis require the involvement of osteoblasts, cells responsible for accumulation and mineralization of the extracellular matrix (ECM). During this complex and only...
6.
Stockwin L, Blonder J, Bumke M, Lucas D, Chan K, Conrads T, et al.
J Proteome Res
. 2006 Nov;
5(11):2996-3007.
PMID: 17081051
Hypoxic conditions often persist within poorly vascularized tumors. At the cellular level constitutive activation of transcriptional regulators of the hypoxic response leads to the emergence of clones with aggressive phenotypes....
7.
Go E, Wikoff W, Shen Z, OMaille G, Morita H, Conrads T, et al.
J Proteome Res
. 2006 Sep;
5(9):2405-16.
PMID: 16944953
Mass spectrometry analysis was used to target three different aspects of the viral infection process: the expression kinetics of viral proteins, changes in the expression levels of cellular proteins, and...
8.
Zhou M, Prieto D, Lucas D, Chan K, Issaq H, Veenstra T, et al.
J Proteome Res
. 2006 Sep;
5(9):2207-16.
PMID: 16944932
Surface-enhanced laser desorption/ionization (SELDI) time-of-flight (TOF) mass spectrometry (MS) has been widely applied for conducting biomarker research with the goal of discovering patterns of proteins and/or peptides from biological samples...
9.
Meng Z, Camalier C, Lucas D, Veenstra T, Beck Jr G, Conrads T
J Proteome Res
. 2006 Aug;
5(8):1931-9.
PMID: 16889415
Current advances in proteomics have allowed for a rapidly expanding integration of associated methodologies with more traditional molecular and biochemical approaches to the study of cell function. Recent studies on...
10.
Yang H, Yu L, Yi M, Lucas D, Lukes L, Lancaster M, et al.
J Proteome Res
. 2006 Jul;
5(7):1555-67.
PMID: 16823962
Tumor metastasis is a complex multistep process normally involving dysregulation of multiple signal transduction pathways. In this study, we developed a novel approach to efficiently define dysreguated pathways associated with...