Kimberly M Lovell
Overview
Explore the profile of Kimberly M Lovell including associated specialties, affiliations and a list of published articles.
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22
Citations
527
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Recent Articles
1.
Ma H, Brust T, Frankowski K, Lovell K, Cameron M, Bohn L, et al.
ACS Chem Neurosci
. 2022 Apr;
13(8):1315-1332.
PMID: 35410469
Focused modification of a sulfonamide-based kappa opioid receptor (KOR) antagonist series previously reported by this laboratory was investigated. A total of 32 analogues were prepared to explore linker replacement, constraint...
2.
Kennedy N, Schmid C, Ross N, Lovell K, Yue Z, Chen Y, et al.
J Med Chem
. 2018 Sep;
61(19):8895-8907.
PMID: 30199635
While mu opioid receptor (MOR) agonists are especially effective as broad-spectrum pain relievers, it has been exceptionally difficult to achieve a clear separation of analgesia from many problematic side effects....
3.
Schmid C, Kennedy N, Ross N, Lovell K, Yue Z, Morgenweck J, et al.
Cell
. 2017 Nov;
171(5):1165-1175.e13.
PMID: 29149605
Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein, we describe structural features of a series...
4.
Lovell K, Frankowski K, Stahl E, Slauson S, Yoo E, Prisinzano T, et al.
ACS Chem Neurosci
. 2017 May;
8(7):1628.
PMID: 28541028
No abstract available.
5.
Scarry S, Lovell K, Frankowski K, Bohn L, Aube J
J Org Chem
. 2016 Jul;
81(21):10538-10550.
PMID: 27399050
The quinoxaline and quinoxalinone family of nitrogen heterocycles is present in molecules of therapeutic relevance for diverse applications ranging from infectious diseases to neuroscience targets. Here, we describe a general...
6.
Zhou L, Stahl E, Lovell K, Frankowski K, Prisinzano T, Aube J, et al.
Neuropharmacology
. 2015 Jul;
99:131-41.
PMID: 26160155
Differential modulation of kappa opioid receptor (KOR) signaling has been a proposed strategy for developing therapies for drug addiction and depression by either activating or blocking this receptor. Hence, there...
7.
Lovell K, Frankowski K, Stahl E, Slauson S, Yoo E, Prisinzano T, et al.
ACS Chem Neurosci
. 2015 Apr;
6(8):1411-9.
PMID: 25891774
Kappa opioid receptor (KOR) modulation is a promising target for drug discovery efforts due to KOR involvement in pain, depression, and addiction behaviors. We recently reported a new class of...
8.
Frankowski K, Slauson S, Lovell K, Phillips A, Streicher J, Zhou L, et al.
Bioorg Med Chem
. 2015 Jan;
23(14):3948-56.
PMID: 25593096
Optimization of the sulfonamide-based kappa opioid receptor (KOR) antagonist probe molecule ML140 through constraint of the sulfonamide nitrogen within a tetrahydroisoquinoline moiety afforded a marked increase in potency. This strategy,...
9.
Raphemot R, Rouhier M, Swale D, Days E, Weaver C, Lovell K, et al.
PLoS One
. 2014 Nov;
9(11):e110772.
PMID: 25375326
Vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. The emergence of insecticide-resistant mosquito populations is reducing...
10.
Caspers M, Williams T, Lovell K, Lozama A, Butelman E, Kreek M, et al.
Anal Methods
. 2014 Jan;
5(24).
PMID: 24416081
A facile method for quantifying the concentration of the powerful and widely available hallucinogen salvinorin A (a selective kappa opioid agonist) from non-human primate cerebrospinal fluid (CSF) and human plasma...