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Kfir Lapid

Explore the profile of Kfir Lapid including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 763
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Recent Articles
1.
Eulberg D, Fromming A, Lapid K, Mangasarian A, Barak A
Front Oncol . 2022 Dec; 12:1070243. PMID: 36568151
Multiple mechanisms promote tumor prosperity, which does not only depend on cell-autonomous, inherent abnormal characteristics of the malignant cells that facilitate rapid cell division and tumor expansion. The neoplastic tissue...
2.
Lapid K, Lim A, Berglund E, Lu Y
Diabetes Metab Syndr Obes . 2019 Oct; 12:1419-1436. PMID: 31616172
Background:  Low estrogen states, exemplified by postmenopausal women, are associated with increased adiposity and metabolic dysfunction. We recently reported a paradox, in which a conditional estrogen receptor-alpha (ERα) mutant mouse...
3.
Lapid K, Graff J
Adipocyte . 2017 Apr; 6(3):176-186. PMID: 28425847
Lipids have the potential to serve as bio-markers, which allow us to analyze and to identify cells under various experimental settings, and to serve as a clinical diagnostic tool. For...
4.
Lapid K, Lim A, Clegg D, Zeve D, Graff J
Nat Commun . 2014 Oct; 5:5196. PMID: 25330806
Oestrogen, often via oestrogen receptor alpha (ERα) signalling, regulates metabolic physiology, highlighted by post-menopausal temperature dysregulation (hot flashes), glucose intolerance, increased appetite and reduced metabolic rate. Here we show that...
5.
Lapid K, Itkin T, DUva G, Ovadya Y, Ludin A, Caglio G, et al.
J Clin Invest . 2013 Mar; 123(4):1705-17. PMID: 23478410
Regulation of hematopoietic stem and progenitor cell (HSPC) steady-state egress from the bone marrow (BM) to the circulation is poorly understood. While glycogen synthase kinase-3β (GSK3β) is known to participate...
6.
Gur-Cohen S, Lapid K, Lapidot T
Methods Mol Biol . 2012 Aug; 904:15-35. PMID: 22890919
Allogeneic donor blood cells and autologous peripheral blood leukocytes (PBL), obtained following -clinical mobilization procedures, are routinely used as a major source of hematopoietic stem and progenitor cells (HSPC) for...
7.
Golan K, Vagima Y, Ludin A, Itkin T, Cohen-Gur S, Kalinkovich A, et al.
Blood . 2012 Jan; 119(11):2478-88. PMID: 22279055
The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate (S1P) receptors by FTY720 as well as...
8.
Shivtiel S, Lapid K, Kalchenko V, Avigdor A, Goichberg P, Kalinkovich A, et al.
Exp Hematol . 2011 Sep; 39(12):1161-1170.e1. PMID: 21911094
Bone marrow homing and engraftment by clinically transplanted hematopoietic stem and progenitor cells is a complex process that is not fully understood. We report that the pan-leukocyte CD45 phosphatase plays...
9.
Vagima Y, Lapid K, Kollet O, Goichberg P, Alon R, Lapidot T
Methods Mol Biol . 2011 May; 750:277-89. PMID: 21618098
The hallmark of hematopoietic stem and progenitor cells (HSPCs) is their motility, which is essential for their function, such as recruitment upon demand. Stromal Derived Factor-1 (SDF-1, CXCL12) and its...
10.
Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, et al.
Leukemia . 2011 Apr; 25(8):1286-1296. PMID: 21494253
Steady-state egress of hematopoietic progenitor cells can be rapidly amplified by mobilizing agents such as AMD3100, the mechanism, however, is poorly understood. We report that AMD3100 increased the homeostatic release...