Kevin T Mellem
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Explore the profile of Kevin T Mellem including associated specialties, affiliations and a list of published articles.
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7
Citations
60
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Recent Articles
1.
Leippe D, Choy R, Vidugiris G, Merritt H, Mellem K, Beattie D, et al.
ACS Omega
. 2024 Aug;
9(30):33072-33080.
PMID: 39100309
Glycogen is a large polymer of glucose that functions as an important means of storing energy and maintaining glucose homeostasis. Glycogen synthesis and degradation pathways are highly regulated and their...
2.
Ullman J, Mellem K, Xi Y, Ramanan V, Merritt H, Choy R, et al.
Sci Transl Med
. 2024 Jan;
16(730):eadf1691.
PMID: 38232139
Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen storage...
3.
Burnett G, Yang Y, Aggen J, Pitzen J, Gliedt M, Semko C, et al.
J Med Chem
. 2022 Dec;
66(1):149-169.
PMID: 36533617
Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple allosteric inhibitors...
4.
Fastman N, Liu Y, Ramanan V, Merritt H, Ambing E, DePaoli-Roach A, et al.
Cell Rep
. 2022 Jul;
40(1):111041.
PMID: 35793618
Glycogen is the primary energy reserve in mammals, and dysregulation of glycogen metabolism can result in glycogen storage diseases (GSDs). In muscle, glycogen synthesis is initiated by the enzymes glycogenin-1...
5.
Mellem K, Myers A
Org Lett
. 2013 Oct;
15(21):5594-7.
PMID: 24138164
A three-step synthesis of pseudoephenamine suitable for preparing multigram amounts of both enantiomers of the auxiliary from the inexpensive starting material benzil is described. The sequence involves synthesis of the...
6.
Hugelshofer C, Mellem K, Myers A
Org Lett
. 2013 Jun;
15(12):3134-7.
PMID: 23746325
The utility of pseudoephenamine as a chiral auxiliary for the alkylative construction of quaternary α-methyl α-amino acids is demonstrated. The method is notable for the high diastereoselectivities of the alkylation...
7.
Morales M, Mellem K, Myers A
Angew Chem Int Ed Engl
. 2012 Mar;
51(19):4568-71.
PMID: 22461381
No abstract available.