Kevin R Marks
Overview
Explore the profile of Kevin R Marks including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
101
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Recent Articles
1.
Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard L, et al.
J Biol Chem
. 2014 Feb;
289(18):12300-12.
PMID: 24497635
DNA gyrase and topoisomerase IV control bacterial DNA topology by breaking DNA, passing duplex DNA through the break, and then resealing the break. This process is subject to reversible corruption...
2.
Marks K, Malik M, Mustaev A, Hiasa H, Drlica K, Kerns R
Bioorg Med Chem Lett
. 2011 Jun;
21(15):4585-8.
PMID: 21705218
Novel fluoroquinolone derivatives substituted with a 2-thioalkyl moiety, with and without a concomitant 3-carboxylate group, were synthesized to evaluate the effect of C-2 thioalkyl substituents on gyrase binding and inhibition....
3.
Malik M, Marks K, Mustaev A, Zhao X, Chavda K, Kerns R, et al.
Antimicrob Agents Chemother
. 2011 Mar;
55(5):2335-43.
PMID: 21383100
Quinazolinediones (diones) are fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV. To assess activity against mycobacteria, C-8-methoxy dione derivatives were compared with cognate fluoroquinolones by using cultured Mycobacterium smegmatis....
4.
Malik M, Marks K, Schwanz H, German N, Drlica K, Kerns R
Antimicrob Agents Chemother
. 2010 Sep;
54(12):5214-21.
PMID: 20855738
Quinolones rapidly kill bacteria by two mechanisms, one that requires protein synthesis and one that does not. The latter, which is measured as lethal action in the presence of the...