Kevin P Campbell
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Explore the profile of Kevin P Campbell including associated specialties, affiliations and a list of published articles.
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172
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8805
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Recent Articles
1.
Hord J, Burns S, Willer T, Goddeeris M, Venzke D, Campbell K
Skelet Muscle
. 2025 Jan;
15(1):1.
PMID: 39789642
Background: Maintaining the connection between skeletal muscle fibers and the surrounding basement membrane is essential for muscle function. Dystroglycan (DG) serves as a basement membrane extracellular matrix (ECM) receptor in...
2.
Wan L, Ge X, Xu Q, Huang G, Yang T, Campbell K, et al.
Nature
. 2024 Dec;
637(8048):1252-1260.
PMID: 39663450
The dystrophin glycoprotein complex (DGC) has a crucial role in maintaining cell membrane stability and integrity by connecting the intracellular cytoskeleton with the surrounding extracellular matrix. Dysfunction of dystrophin and...
3.
Ma K, Huang S, Ng K, Lake N, Joseph S, Xu J, et al.
Cell
. 2024 Sep;
187(23):6707-6724.e22.
PMID: 39326416
Interpretation of disease-causing genetic variants remains a challenge in human genetics. Current costs and complexity of deep mutational scanning methods are obstacles for achieving genome-wide resolution of variants in disease-related...
4.
Hord J, Anderson M, Prouty S, Melton S, Gastel Z, Zimmerman K, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(22):e2402890121.
PMID: 38771868
Maintaining the structure of cardiac membranes and membrane organelles is essential for heart function. A critical cardiac membrane organelle is the transverse tubule system (called the t-tubule system) which is...
5.
Yang T, Chandel I, Gonzales M, Okuma H, Prouty S, Zarei S, et al.
bioRxiv
. 2024 Jan;
PMID: 38187633
Matriglycan (-1,3-β-glucuronic acid-1,3-α-xylose-) is a polysaccharide that is synthesized on α-dystroglycan, where it functions as a high-affinity glycan receptor for extracellular proteins, such as laminin, perlecan and agrin, thus anchoring...
6.
Ma K, Huang S, Ng K, Lake N, Joseph S, Xu J, et al.
bioRxiv
. 2023 Oct;
PMID: 37873263
Interpretation of disease-causing genetic variants remains a challenge in human genetics. Current costs and complexity of deep mutational scanning methods hamper crowd-sourcing approaches toward genome-wide resolution of variants in disease-related...
7.
Chandel I, Campbell K
Bio Protoc
. 2023 Sep;
13(18):e4827.
PMID: 37753476
n that is uniquely synthesized on α-dystroglycan (α-DG) and is essential for neuromuscular function and brain development. It binds several extracellular matrix proteins that contain laminin-globular domains and is a...
8.
Okuma H, Hord J, Chandel I, Venzke D, Anderson M, Walimbe A, et al.
Elife
. 2023 Feb;
12.
PMID: 36723429
Dystroglycan (DG) requires extensive post-translational processing and -glycosylation to function as a receptor for extracellular matrix (ECM) proteins containing laminin-G (LG) domains. Matriglycan is an elongated polysaccharide of alternating xylose...
9.
Sheikh M, Capicciotti C, Liu L, Praissman J, Ding D, Mead D, et al.
Nat Commun
. 2022 Jun;
13(1):3617.
PMID: 35750689
α-Dystroglycan (α-DG) is uniquely modified on O-mannose sites by a repeating disaccharide (-Xylα1,3-GlcAβ1,3-) termed matriglycan, which is a receptor for laminin-G domain-containing proteins and employed by old-world arenaviruses for infection....
10.
Yonekawa T, Rauckhorst A, El-Hattab S, Cuellar M, Venzke D, Anderson M, et al.
Sci Adv
. 2022 May;
8(21):eabn0379.
PMID: 35613260
Muscular dystrophy is a progressive and ultimately lethal neuromuscular disease. Although gene editing and gene transfer hold great promise as therapies when administered before the onset of severe clinical symptoms,...