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Daniel E Michele

Explore the profile of Daniel E Michele including associated specialties, affiliations and a list of published articles. Areas
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Articles 55
Citations 2402
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Recent Articles
1.
Chen H, Michele D
Am J Physiol Cell Physiol . 2024 Dec; 328(2):C429-C439. PMID: 39726261
Plasma membrane repair (PMR) restores membrane integrity of cells, preventing cell death in vital organs, and has been studied extensively in skeletal muscle. Dysferlin, a sarcolemmal Ca-binding protein, plays a...
2.
Buras E, Woo M, Kaul Verma R, Kondisetti S, Davis C, Claflin D, et al.
JCI Insight . 2024 Jul; 9(16). PMID: 38954467
Pulmonary disorders affect 40%-80% of individuals with obesity. Respiratory muscle dysfunction is linked to these conditions; however, its pathophysiology remains largely undefined. Mice subjected to diet-induced obesity (DIO) develop diaphragm...
3.
Lacy S, Taubitz R, Urban N, Turowski S, Smith E, Helms A, et al.
bioRxiv . 2024 Jun; PMID: 38853840
Cardiomyocytes require the HSP70 chaperone BiP to maintain proteostasis in the endoplasmic reticulum (ER) following cardiac stress. The adenylyl transferase (AMPylase) FICD is increasingly recognized to regulate BiP activity through...
4.
Buras E, Woo M, Kaul Verma R, Kondisetti S, Davis C, Claflin D, et al.
bioRxiv . 2023 Aug; PMID: 37645822
Pulmonary disorders impact 40-80% of individuals with obesity. Respiratory muscle dysfunction is linked to these conditions; however, its pathophysiology remains largely undefined. Mice subjected to diet-induced obesity (DIO) develop diaphragmatic...
5.
Willi L, Abramovich I, Fernandez-Garcia J, Agranovich B, Shulman M, Milman H, et al.
Int J Mol Sci . 2022 Sep; 23(17). PMID: 36077200
Duchenne muscular dystrophy (DMD) is caused by mutations in the gene and dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in DMD patients. We tested the hypothesis...
6.
Michele D
FEBS J . 2022 Aug; 289(21):6460-6462. PMID: 35929418
Skeletal muscle is a structurally and functionally remarkable tissue composed of multinucleated post-mitotic muscle fibres. These fibres are filled with an exquisite, near crystalline array of assembled contractile proteins, capable...
7.
Jimenez-Vazquez E, Arad M, Macias A, Vera-Pedrosa M, Cruz F, Gutierrez L, et al.
Elife . 2022 Jun; 11. PMID: 35762211
Background: Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown. We aimed to determine the role of ion channels...
8.
Lopez R, Marzban B, Gao X, Lauinger E, Van den Bergh F, Whitesall S, et al.
Function (Oxf) . 2020 Oct; 1(2):zqaa018. PMID: 33074265
Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive the molecular processes underlying cardiac pumping. Physiological rates of myocardial ATP consumption require the heart...
9.
Gu F, Randall E, Whitesall S, Converso-Baran K, Carlson B, Fink G, et al.
JCI Insight . 2020 Oct; 5(19). PMID: 33004690
The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model,...
10.
McDade J, Naylor M, Michele D
FEBS J . 2020 Sep; 288(1):160-174. PMID: 32893434
Plasma membrane repair is an evolutionarily conserved mechanism by which cells can seal breaches in the plasma membrane. Mutations in several proteins with putative roles in sarcolemma integrity, membrane repair,...