Kevin M Tharp
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Explore the profile of Kevin M Tharp including associated specialties, affiliations and a list of published articles.
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Citations
497
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Recent Articles
1.
Kahlon U, Ricca F, Pillai S, Olivetta M, Tharp K, Jao L, et al.
bioRxiv
. 2024 Nov;
PMID: 39553983
Embryos undergo pre-gastrulation cleavage cycles to generate a critical cell mass before transitioning to morphogenesis. The molecular underpinnings of this transition have traditionally centered on zygotic chromatin remodeling and genome...
2.
Tharp K
Br J Pharmacol
. 2024 Nov;
PMID: 39491545
Conventional cell culture techniques generally fail to recapitulate the expression profiles or functional phenotypes of the in vivo equivalents they are meant to model. These cell culture models are indispensable...
3.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Minor C, et al.
PLoS One
. 2024 Sep;
19(9):e0302673.
PMID: 39264947
Mechanical stress is a measure of internal resistance exhibited by a body or material when external forces, such as compression, tension, bending, etc. are applied. The study of mechanical stress...
4.
Yadav P, Ortega J, Tamaki W, Chien C, Chang K, Biswas N, et al.
bioRxiv
. 2024 Aug;
PMID: 39211079
Monocyte-derived macrophages recruited to injured tissues induce a maladaptive fibrotic response characterized by excessive production of collagen by local fibroblasts. Macrophages initiate this programming via paracrine factors, but it is...
5.
Tharp K, Kersten K, Maller O, Timblin G, Stashko C, Canale F, et al.
Nat Cancer
. 2024 Jun;
5(7):1045-1062.
PMID: 38831058
Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix accumulation, which is associated with diminished antitumor immune infiltration. Here we demonstrate that tumor-associated macrophages (TAMs) respond to...
6.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Castro Torres T, et al.
bioRxiv
. 2024 Apr;
PMID: 38645203
Mechanical stress is a measure of internal resistance exhibited by a body or material when external forces, such as compression, tension, bending, etc. are applied. The study of mechanical stress...
7.
Tharp K, Park S, Timblin G, Richards A, Berg J, Twells N, et al.
Res Sq
. 2023 Aug;
PMID: 37645943
Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are built with models that do not match the microenvironmental characteristics of human tissues. Using models which mimic the physical properties...
8.
Kersten K, You R, Liang S, Tharp K, Pollack J, Weaver V, et al.
Cell Rep
. 2023 Jun;
42(6):112582.
PMID: 37261951
Pre-metastatic niche formation is a critical step during the metastatic spread of cancer. One way by which primary tumors prime host cells at future metastatic sites is through the shedding...
9.
Ferguson I, Lin Y, Lam C, Shao H, Tharp K, Hale M, et al.
Cell Chem Biol
. 2022 Jul;
29(8):1288-1302.e7.
PMID: 35853457
Proteasome inhibitor (PI) resistance remains a central challenge in multiple myeloma. To identify pathways mediating resistance, we first mapped proteasome-associated genetic co-dependencies. We identified heat shock protein 70 (HSP70) chaperones...
10.
Moehle E, Higuchi-Sanabria R, Tsui C, Homentcovschi S, Tharp K, Zhang H, et al.
Sci Adv
. 2021 Oct;
7(44):eabj6818.
PMID: 34714674
The dysfunction of mitochondria is associated with the physiological consequences of aging and many age-related diseases. Therefore, critical quality control mechanisms exist to protect mitochondrial functions, including the unfolded protein...