Kevin M Tharp
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Explore the profile of Kevin M Tharp including associated specialties, affiliations and a list of published articles.
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25
Citations
497
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Recent Articles
11.
Timblin G, Tharp K, Ford B, Winchester J, Wang J, Zhu S, et al.
Nat Metab
. 2021 May;
3(5):618-635.
PMID: 34031590
Macrophages generate mitochondrial reactive oxygen species and mitochondrial reactive electrophilic species as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules impacts macrophage function is...
12.
Tharp K, Higuchi-Sanabria R, Timblin G, Ford B, Garzon-Coral C, Schneider C, et al.
Cell Metab
. 2021 May;
33(7):1322-1341.e13.
PMID: 34019840
Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programed cell death. The biochemical milieu is known to affect mitochondrial...
13.
Hughes J, Ewy J, Chen J, Wong S, Tharp K, Stahl A, et al.
Matrix Biol
. 2019 Jun;
85-86:112-127.
PMID: 31189077
The poor prognosis of glioblastoma (GBM) is associated with a highly invasive stem-like subpopulation of tumor-initiating cells (TICs), which drive recurrence and contribute to intra-tumoral heterogeneity through differentiation. These TICs...
14.
Tharp K, Weaver V
J Mol Biol
. 2018 Jul;
430(19):3613-3628.
PMID: 30055167
Polarity is critical for development and tissue-specific function. However, the acquisition and maintenance of tissue polarity is context dependent. Thus, cell and tissue polarity depend on cell adhesion which is...
15.
Tharp K, Kang M, Timblin G, Dempersmier J, Dempsey G, Zushin P, et al.
Cell Metab
. 2018 Mar;
27(3):602-615.e4.
PMID: 29514068
The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protein 1 (UCP1) expression are essential for BAT-based strategies to improve metabolic homeostasis. Here, we demonstrate that...
16.
Loskill P, Sezhian T, Tharp K, Lee-Montiel F, Jeeawoody S, Reese W, et al.
Lab Chip
. 2017 Apr;
17(9):1645-1654.
PMID: 28418430
Organ-on-a-chip systems possess a promising future as drug screening assays and as testbeds for disease modeling in the context of both single-organ systems and multi-organ-chips. Although it comprises approximately one...
17.
Secco B, Camire E, Briere M, Caron A, Billong A, Gelinas Y, et al.
Cell Rep
. 2017 Jan;
18(1):93-106.
PMID: 28052263
Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating...
18.
Sambeat A, Gulyaeva O, Dempersmier J, Tharp K, Stahl A, Paul S, et al.
Cell Rep
. 2016 Jun;
15(11):2536-49.
PMID: 27264172
Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct...
19.
Khalifeh-Soltani A, Ha A, Podolsky M, McCarthy D, McKleroy W, Azary S, et al.
Elife
. 2016 Apr;
5.
PMID: 27092791
Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the...
20.
Tharp K, Khalifeh-Soltani A, Park H, Yurek D, Falcon A, Wong L, et al.
Am J Physiol Gastrointest Liver Physiol
. 2016 Apr;
310(10):G855-64.
PMID: 27033116
Gallstone disease is a widespread disorder costing billions for annual treatment in the United States. The primary mechanisms underlying gallstone formation are biliary cholesterol supersaturation and gallbladder hypomotility. The relative...