Kevin J Schwartz
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Explore the profile of Kevin J Schwartz including associated specialties, affiliations and a list of published articles.
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17
Citations
568
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Recent Articles
1.
Banerjee R, Weisenhorn E, Schwartz K, Myers K, Glasner J, Perna N, et al.
mBio
. 2020 Mar;
11(2).
PMID: 32209682
Pathogenicity islands and plasmids bear genes for pathogenesis of various pathotypes. Although there is a basic understanding of the contribution of these virulence factors to disease, less is known about...
2.
Koeller C, Tiengwe C, Schwartz K, Bangs J
J Biol Chem
. 2020 Jan;
295(8):2227-2238.
PMID: 31932305
The transferrin receptor (TfR) of the bloodstream form (BSF) of is a heterodimer comprising glycosylphosphatidylinositol (GPI)-anchored expression site-associated gene 6 (ESAG6 or E6) and soluble ESAG7. Mature E6 has five...
3.
Ristow L, Tran V, Schwartz K, Pankratz L, Mehle A, Sauer J, et al.
mBio
. 2019 Jul;
10(4).
PMID: 31289186
The hemolysin (HlyA) is a pore-forming exotoxin associated with severe complications of human urinary tract infections. HlyA is the prototype of the repeats-in-toxin (RTX) family, which includes LtxA from ,...
4.
Hryckowian A, Baisa G, Schwartz K, Welch R
PLoS One
. 2015 Sep;
10(9):e0138121.
PMID: 26366567
The urinary tract environment provides many conditions that deter colonization by microorganisms. D-serine is thought to be one of these stressors and is present at high concentrations in urine. D-serine...
5.
Raterman E, Shapiro D, Stevens D, Schwartz K, Welch R
Infect Immun
. 2013 Jun;
81(9):3089-98.
PMID: 23774594
During urinary tract infections (UTIs), uropathogenic Escherichia coli must maintain a delicate balance between sessility and motility to achieve successful infection of both the bladder and kidneys. Previous studies showed...
6.
Schwartz K, Peck R, Bangs J
Eukaryot Cell
. 2012 Nov;
12(1):132-41.
PMID: 23159520
Trypanosoma brucei protein disulfide isomerase 2 (TbPDI2) is a bloodstream stage-specific lumenal endoplasmic reticulum (ER) glycoprotein. ER localization is dependent on the TbPDI2 C-terminal tetrapeptide (KQDL) and is mediated by...
7.
Silverman J, Schwartz K, Hajduk S, Bangs J
Mol Microbiol
. 2011 Sep;
82(3):664-78.
PMID: 21923766
We present the first functional analysis of the small GTPase, TbRab7, in Trypanosoma brucei. TbRab7 defines discrete late endosomes closely juxtaposed to the terminal p67(+) lysosome. RNAi indicates that TbRab7...
8.
Sevova E, Goren M, Schwartz K, Hsu F, Turk J, Fox B, et al.
J Biol Chem
. 2010 May;
285(27):20580-7.
PMID: 20457606
The Trypanosoma brucei genome has four highly similar genes encoding sphingolipid synthases (TbSLS1-4). TbSLSs are polytopic membrane proteins that are essential for viability of the pathogenic bloodstream stage of this...
9.
Tazeh N, Silverman J, Schwartz K, Sevova E, Sutterwala S, Bangs J
Eukaryot Cell
. 2009 Jul;
8(9):1352-61.
PMID: 19581441
African trypanosomes are the causative agents of human trypanosomiasis (sleeping sickness). The pathogenic stage of the parasite has unique adaptations to life in the bloodstream of the mammalian host, including...
10.
Sutterwala S, Hsu F, Sevova E, Schwartz K, Zhang K, Key P, et al.
Mol Microbiol
. 2008 Aug;
70(2):281-96.
PMID: 18699867
Sphingolipids are essential components of eukaryotic membranes, and many unicellular eukaryotes, including kinetoplastid protozoa, are thought to synthesize exclusively inositol phosphorylceramide (IPC). Here we characterize sphingolipids from Trypanosoma brucei, and...