Stephen L Hajduk
Overview
Explore the profile of Stephen L Hajduk including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
40
Citations
839
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in
Kieft R, Cliffe L, Yan H, Schmitz R, Hajduk S, Sabatini R
mBio
. 2024 Dec;
16(2):e0232824.
PMID: 39704500
Unique for a eukaryote, protein-coding genes in trypanosomes are arranged in polycistronic transcription units (PTUs). This genome arrangement has led to a model where Pol II transcription of PTUs is...
2.
Kieft R, Cliffe L, Yan H, Schmitz R, Hajduk S, Sabatini R
bioRxiv
. 2024 Jul;
PMID: 38948844
Importance: The single-cell parasite causes lethal diseases in both humans and livestock. undergoes multiple developmental changes to adapt in different environments during its digenetic life cycle. With protein-coding genes organized...
3.
Sharma A, Cipriano M, Ferrins L, Hajduk S, Mensa-Wilmot K
iScience
. 2022 Oct;
25(11):105302.
PMID: 36304107
NEU-4438 is a lead for the development of drugs against , which causes human African trypanosomiasis. Optimized with phenotypic screening, targets of NEU-4438 are unknown. Herein, we present a cell...
4.
Garrison P, Khan U, Cipriano M, Bush P, McDonald J, Sur A, et al.
mBio
. 2021 Jul;
12(4):e0172521.
PMID: 34311578
African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous...
5.
Cipriano M, Hajduk S
Essays Biochem
. 2018 Apr;
62(2):135-147.
PMID: 29666211
Extracellular vesicles (EVs) are produced by invading pathogens and also by host cells in response to infection. The origin, composition, and function of EVs made during infection are diverse and...
6.
7.
Szempruch A, Dennison L, Kieft R, Harrington J, Hajduk S
Nat Rev Microbiol
. 2016 Sep;
14(11):669-675.
PMID: 27615028
Parasitic unicellular eukaryotes use extracellular vesicles (EVs) as vehicles for intercellular communication and host manipulation. By using various mechanisms to generate EVs and by transferring a wide range of molecules...
8.
Szempruch A, Sykes S, Kieft R, Dennison L, Becker A, Gartrell A, et al.
Cell
. 2016 Jan;
164(1-2):246-257.
PMID: 26771494
Intercellular communication between parasites and with host cells provides mechanisms for parasite development, immune evasion, and disease pathology. Bloodstream African trypanosomes produce membranous nanotubes that originate from the flagellar membrane...
9.
Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei brucei
Greene A, Hajduk S
J Biol Chem
. 2015 Dec;
291(6):3063-75.
PMID: 26645690
Human innate immunity against the veterinary pathogen Trypanosoma brucei brucei is conferred by trypanosome lytic factors (TLFs), against which human-infective T. brucei gambiense and T. brucei rhodesiense have evolved resistance....
10.
Szempruch A, Choudhury R, Wang Z, Hajduk S
RNA
. 2015 Aug;
21(10):1781-9.
PMID: 26264591
Trypanosomes possess a unique mitochondrial genome called the kinetoplast DNA (kDNA). Many kDNA genes encode pre-mRNAs that must undergo guide RNA-directed editing. In addition, alternative mRNA editing gives rise to...