Kevin H Strang
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Explore the profile of Kevin H Strang including associated specialties, affiliations and a list of published articles.
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13
Citations
519
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Recent Articles
1.
Xia Y, Prokop S, Bell B, Gorion K, Croft C, Nasif L, et al.
Commun Biol
. 2022 May;
5(1):446.
PMID: 35550593
Pathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. We generated and characterized a transgenic mouse model expressing pathogenic human tau with S320F and P301S aggregating mutations (SPAM) at...
2.
Bowles K, Silva M, Whitney K, Bertucci T, Berlind J, Lai J, et al.
Cell
. 2021 Jul;
184(17):4547-4563.e17.
PMID: 34314701
Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We used human induced pluripotent stem cell (iPSC)-derived cerebral organoids...
3.
Xia Y, Sorrentino Z, Kim J, Strang K, Riffe C, Giasson B
J Biol Chem
. 2019 Oct;
294(48):18488-18503.
PMID: 31653695
tau is a microtubule (MT)-associated protein that promotes tubulin assembly and stabilizes MTs by binding longitudinally along the MT surface. tau can aberrantly aggregate into pathological inclusions that define Alzheimer's...
4.
Koller E, De La Cruz E, Machula T, Ibanez K, Lin W, Williams T, et al.
Hum Mol Genet
. 2019 Jul;
28(19):3255-3269.
PMID: 31261380
Understanding the biological functions of tau variants can illuminate differential etiologies of Alzheimer's disease (AD) and primary tauopathies. Though the end-stage neuropathological attributes of AD and primary tauopathies are similar,...
5.
Croft C, Cruz P, Ryu D, Ceballos-Diaz C, Strang K, Woody B, et al.
J Exp Med
. 2019 Feb;
216(3):539-555.
PMID: 30770411
It has been challenging to produce ex vivo models of the inclusion pathologies that are hallmark pathologies of many neurodegenerative diseases. Using three-dimensional mouse brain slice cultures (BSCs), we have...
6.
Strang K, Golde T, Giasson B
Lab Invest
. 2019 Feb;
99(7):912-928.
PMID: 30742061
In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent pathological feature is the aberrant aggregation and inclusion formation of the microtubule-associated protein tau. Because of the pathological association, these...
7.
Strang K, Sorrentino Z, Riffe C, Gorion K, Vijayaraghavan N, Golde T, et al.
Neurosci Lett
. 2018 Nov;
692:187-192.
PMID: 30423399
Alzheimer's disease and other tauopathies are characterized by the brain accumulation of hyperphosphorylated aggregated tau protein forming pathological inclusions. Although elevated tau phosphorylated at many amino acid residues is a...
8.
Sorrentino Z, Vijayaraghavan N, Gorion K, Riffe C, Strang K, Caldwell J, et al.
J Biol Chem
. 2018 Oct;
293(49):18914-18932.
PMID: 30327435
α-Synuclein (αsyn) aggregates into toxic fibrils in multiple neurodegenerative diseases where these fibrils form characteristic pathological inclusions such as Lewy bodies (LBs). The mechanisms initiating αsyn aggregation into fibrils are...
9.
Strang K, Croft C, Sorrentino Z, Chakrabarty P, Golde T, Giasson B
J Biol Chem
. 2018 Mar;
293(12):4579.
PMID: 29572329
No abstract available.
10.
Strang K, Croft C, Sorrentino Z, Chakrabarty P, Golde T, Giasson B
J Biol Chem
. 2017 Dec;
293(7):2408-2421.
PMID: 29259137
The accumulation of aberrantly aggregated MAPT (microtubule-associated protein Tau) defines a spectrum of tauopathies, including Alzheimer's disease. Mutations in the gene cause frontotemporal dementia with Parkinsonism linked to chromosome 17...