Kevin C Flanagan
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Explore the profile of Kevin C Flanagan including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
546
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0
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Recent Articles
11.
Nickless A, Cheruiyot A, Flanagan K, Piwnica-Worms D, Stewart S, You Z
J Biol Chem
. 2017 Aug;
292(37):15266-15276.
PMID: 28765281
Persistent DNA damage induces profound alterations in gene expression that, in turn, influence tissue homeostasis, tumorigenesis, and cancer treatment outcome. However, the underlying mechanism for gene expression reprogramming induced by...
12.
Ruhland M, Loza A, Capietto A, Luo X, Knolhoff B, Flanagan K, et al.
Nat Commun
. 2016 Jun;
7:11762.
PMID: 27272654
Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To determine if senescent stromal cells influence...
13.
Alspach E, Flanagan K, Luo X, Ruhland M, Huang H, Pazolli E, et al.
Cancer Discov
. 2014 Mar;
4(6):716-29.
PMID: 24670723
Unlabelled: Neoplastic cells rely on the tumor microenvironment (TME) for survival and progression factors. Indeed, senescent and cancer-associated fibroblasts (CAF) express factors that promote tumorigenesis that are collectively referred to...
14.
Jagannath A, Butler R, Godinho S, Couch Y, Brown L, Vasudevan S, et al.
Cell
. 2013 Sep;
154(5):1100-1111.
PMID: 23993098
Retinal photoreceptors entrain the circadian system to the solar day. This photic resetting involves cAMP response element binding protein (CREB)-mediated upregulation of Per genes within individual cells of the suprachiasmatic...
15.
Luyendyk J, Flanagan K, Williams C, Jaeschke H, Slusser J, Mackman N, et al.
Toxicol Appl Pharmacol
. 2010 Nov;
250(3):256-62.
PMID: 21070799
Cholestatic liver injury induced by alpha-naphthylisothiocyanate (ANIT) is provoked by injury to intrahepatic bile ducts and the progression of hepatic necrosis requires the procoagulant protein tissue factor (TF) and extrahepatic...