David N Messina
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Explore the profile of David N Messina including associated specialties, affiliations and a list of published articles.
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15
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1360
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Recent Articles
1.
Hiken J, Earls J, Flanagan K, Wellinghoff R, Ponder M, Messina D, et al.
BMC Cancer
. 2025 Jan;
25(1):21.
PMID: 39773366
Background: While immune checkpoint inhibitor (ICI) therapies can significantly improve outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC), only about 15-20% benefit from such treatments. Clinical...
2.
Flanagan K, Earls J, Hiken J, Wellinghoff R, Ponder M, McLeod H, et al.
J Immunother Cancer
. 2024 Nov;
12(11).
PMID: 39489541
Background: Despite advances in cancer care and detection, >65% of patients with squamous cell cancer of the head and neck (HNSCC) will develop recurrent and/or metastatic disease. The prognosis for...
3.
Flanagan K, Earls J, Schillebeeckx I, Hiken J, Wellinghoff R, LaFranzo N, et al.
J Cancer Res Clin Oncol
. 2023 Aug;
149(15):14125-14136.
PMID: 37552307
Purpose: Anti-PD-1 therapy provides clinical benefit in 40-50% of patients with relapsed and/or metastatic head and neck squamous cell carcinoma (RM-HNSCC). Selection of anti- PD-1 therapy is typically based on...
4.
Schillebeeckx I, Earls J, Flanagan K, Hiken J, Bode A, Armstrong J, et al.
Sci Rep
. 2022 Jan;
12(1):1342.
PMID: 35079117
Anti-PD-1 therapy can provide long, durable benefit to a fraction of patients. The on-label PD-L1 test, however, does not accurately predict response. To build a better biomarker, we created a...
5.
Harrison N, Fritz A, Glasscock J, Ahmed S, Messina D, Amand P, et al.
Plant Genome
. 2020 Nov;
8(2):eplantgenome2014.08.0040.
PMID: 33228321
Leaf rust, caused by Puccinia triticina Eriks., is one of the most widespread diseases of wheat and breeding for resistance is one of the most effective methods of control. Lr16...
6.
Schillebeeckx I, Armstrong J, Forys J, Hiken J, Earls J, Flanagan K, et al.
J Mol Diagn
. 2020 Feb;
22(4):555-570.
PMID: 32036085
As immuno-oncology drugs grow more popular in the treatment of cancer, better methods are needed to quantify the tumor immune cell component to determine which patients are most likely to...
7.
Barrientos-Somarribas M, Messina D, Pou C, Lysholm F, Bjerkner A, Allander T, et al.
Sci Rep
. 2018 Jan;
8(1):28.
PMID: 29311716
Massive amounts of metagenomics data are currently being produced, and in all such projects a sizeable fraction of the resulting data shows no or little homology to known sequences. It...
8.
Boothby T, Tenlen J, Smith F, Wang J, Patanella K, Nishimura E, et al.
Proc Natl Acad Sci U S A
. 2015 Nov;
112(52):15976-81.
PMID: 26598659
Horizontal gene transfer (HGT), or the transfer of genes between species, has been recognized recently as more pervasive than previously suspected. Here, we report evidence for an unprecedented degree of...
9.
Schmitt T, Messina D, Schreiber F, Sonnhammer E
Brief Bioinform
. 2011 Jun;
12(5):485-8.
PMID: 21666252
There is a great need for standards in the orthology field. Users must contend with different ortholog data representations from each provider, and the providers themselves must independently gather and...
10.
Ostlund G, Schmitt T, Forslund K, Kostler T, Messina D, Roopra S, et al.
Nucleic Acids Res
. 2009 Nov;
38(Database issue):D196-203.
PMID: 19892828
The InParanoid project gathers proteomes of completely sequenced eukaryotic species plus Escherichia coli and calculates pairwise ortholog relationships among them. The new release 7.0 of the database has grown by...