Kenneth C Bedi Jr
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Explore the profile of Kenneth C Bedi Jr including associated specialties, affiliations and a list of published articles.
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25
Citations
1223
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Recent Articles
1.
Hill M, Simonson B, Roselli C, Xiao L, Herndon C, Chaffin M, et al.
Nat Commun
. 2024 Nov;
15(1):10002.
PMID: 39562555
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans, yet the molecular basis of AF remains incompletely understood. To determine the cell type-specific transcriptional changes underlying AF, we...
2.
Tamayo I, Lee H, Aslam M, Liu J, Ragi N, Karanam V, et al.
medRxiv
. 2024 Sep;
PMID: 39228698
Mechanisms underlying the cardiovascular-kidney-metabolic (CKM) syndrome are unknown, although key small molecule metabolites may be involved. Bulk and spatial metabolomics identified adenine to be upregulated and specifically enriched in coronary...
3.
Lazaropoulos M, Gibb A, Chapski D, Nair A, Reiter A, Roy R, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(7):869-882.
PMID: 39196175
Differentiation of cardiac fibroblasts to myofibroblasts is necessary for matrix remodeling and fibrosis in heart failure. We previously reported that mitochondrial calcium signaling drives α-ketoglutarate-dependent histone demethylation, promoting myofibroblast formation....
4.
Eaton D, Lee B, Caporizzo M, Iyengar A, Chen C, Uchida K, et al.
Sci Transl Med
. 2024 Jul;
16(756):eadm8842.
PMID: 39018366
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated with increased myocardial stiffness and cardiac filling abnormalities. Prior studies implicated increased α-tubulin detyrosination, which is catalyzed by...
5.
Nollet E, Schuldt M, Sequeira V, Binek A, Pham T, Schoonvelde S, et al.
Circ Genom Precis Med
. 2024 Jun;
17(3):e004369.
PMID: 38853772
Background: Hypertrophic cardiomyopathy (HCM) is caused by sarcomere gene mutations (genotype-positive HCM) in ≈50% of patients and occurs in the absence of mutations (genotype-negative HCM) in the other half of...
6.
McAfee Q, Caporizzo M, Uchida K, Bedi Jr K, Margulies K, Arany Z, et al.
J Clin Invest
. 2023 Nov;
134(2).
PMID: 37943622
No abstract available.
7.
Lee B, Caporizzo M, Chen C, Bedi Jr K, Peyster E, Prosser B, et al.
Am J Physiol Heart Circ Physiol
. 2023 Aug;
325(4):H814-H821.
PMID: 37566108
Osteogenesis imperfecta (OI) is an extracellular matrix disorder characterized by defects in collagen-1 transport or synthesis, resulting in bone abnormalities. Although reduced collagen in OI hearts has been associated with...
8.
Hahn V, Petucci C, Kim M, Bedi Jr K, Wang H, Mishra S, et al.
Circulation
. 2023 Mar;
147(15):1147-1161.
PMID: 36856044
Background: The human heart primarily metabolizes fatty acids, and this decreases as alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with severe obesity and diabetes...
9.
Simonson B, Chaffin M, Hill M, Atwa O, Guedira Y, Bhasin H, et al.
Cell Rep
. 2023 Feb;
42(2):112086.
PMID: 36790929
Ischemic cardiomyopathy (ICM) is the leading cause of heart failure worldwide, yet the cellular and molecular signature of this disease is largely unclear. Using single-nucleus RNA sequencing (snRNA-seq) and integrated...
10.
Flam E, Jang C, Murashige D, Yang Y, Morley M, Jung S, et al.
Nat Cardiovasc Res
. 2023 Feb;
1(9):817-829.
PMID: 36776621
Heart failure (HF) is a leading cause of mortality. Failing hearts undergo profound metabolic changes, but a comprehensive evaluation in humans is lacking. We integrate plasma and cardiac tissue metabolomics...